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The PI3K/Akt signaling pathway regulates the expression of Hsp70, which critically contributes to Hsp90-chaperone function and tumor cell survival in multiple myeloma.
Chatterjee M, Andrulis M, Stühmer T, Müller E, Hofmann C, Steinbrunn T, Heimberger T, Schraud H, Kressmann S, Einsele H, Bargou RC. Chatterjee M, et al. Among authors: kressmann s. Haematologica. 2013 Jul;98(7):1132-41. doi: 10.3324/haematol.2012.066175. Epub 2012 Oct 12. Haematologica. 2013. PMID: 23065523 Free PMC article.