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Heteromeric canonical transient receptor potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration.
Phelan KD, Mock MM, Kretz O, Shwe UT, Kozhemyakin M, Greenfield LJ, Dietrich A, Birnbaumer L, Freichel M, Flockerzi V, Zheng F. Phelan KD, et al. Among authors: kretz o. Mol Pharmacol. 2012 Mar;81(3):384-92. doi: 10.1124/mol.111.075341. Epub 2011 Dec 5. Mol Pharmacol. 2012. PMID: 22144671 Free PMC article.
Male fertility depends on Ca²+ absorption by TRPV6 in epididymal epithelia.
Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Vennekens R, Wissenbach U, Middendorff R, Flockerzi V, Freichel M. Weissgerber P, et al. Among authors: kretz o. Sci Signal. 2011 May 3;4(171):ra27. doi: 10.1126/scisignal.2001791. Sci Signal. 2011. PMID: 21540454
Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation.
Weissgerber P, Kriebs U, Tsvilovskyy V, Olausson J, Kretz O, Stoerger C, Mannebach S, Wissenbach U, Vennekens R, Middendorff R, Flockerzi V, Freichel M. Weissgerber P, et al. Among authors: kretz o. J Biol Chem. 2012 May 25;287(22):17930-41. doi: 10.1074/jbc.M111.328286. Epub 2012 Mar 15. J Biol Chem. 2012. PMID: 22427671 Free PMC article.
Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels in mice disrupts Ca(2+) absorption by the epididymal epithelium, resulting in abnormally high Ca(2+) concentrations in epididymal luminal fluid and in a dramatic but incomplete loss of sperm mot …
Replacement of aspartate residue 541 by alanine (D541A) in the pore of TRPV6 channels in mice disrupts Ca(2+) absorption by the epididymal e …
Hippocampal synapses depend on hippocampal estrogen synthesis.
Kretz O, Fester L, Wehrenberg U, Zhou L, Brauckmann S, Zhao S, Prange-Kiel J, Naumann T, Jarry H, Frotscher M, Rune GM. Kretz O, et al. J Neurosci. 2004 Jun 30;24(26):5913-21. doi: 10.1523/JNEUROSCI.5186-03.2004. J Neurosci. 2004. PMID: 15229239 Free PMC article.
150 results