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A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies.
Gu WZ, Joseph I, Wang YC, Frost D, Sullivan GM, Wang L, Lin NH, Cohen J, Stoll VS, Jakob CG, Muchmore SW, Harlan JE, Holzman T, Walten KA, Ladror US, Anderson MG, Kroeger P, Rodriguez LE, Jarvis KP, Ferguson D, Marsh K, Ng S, Rosenberg SH, Sham HL, Zhang H. Gu WZ, et al. Anticancer Drugs. 2005 Nov;16(10):1059-69. doi: 10.1097/00001813-200511000-00004. Anticancer Drugs. 2005. PMID: 16222147
PKCtheta is a key player in the development of insulin resistance.
Haasch D, Berg C, Clampit JE, Pederson T, Frost L, Kroeger P, Rondinone CM. Haasch D, et al. Biochem Biophys Res Commun. 2006 May 5;343(2):361-8. doi: 10.1016/j.bbrc.2006.02.177. Epub 2006 Mar 9. Biochem Biophys Res Commun. 2006. PMID: 16545776
siRNA-mediated gene silencing: a global genome view.
Semizarov D, Kroeger P, Fesik S. Semizarov D, et al. Nucleic Acids Res. 2004 Jul 22;32(13):3836-45. doi: 10.1093/nar/gkh714. Print 2004. Nucleic Acids Res. 2004. PMID: 15272085 Free PMC article.
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