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The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus.
Burgdorf J, Zhang XL, Weiss C, Gross A, Boikess SR, Kroes RA, Khan MA, Burch RM, Rex CS, Disterhoft JF, Stanton PK, Moskal JR. Burgdorf J, et al. Among authors: kroes ra. Neuroscience. 2015 Nov 12;308:202-11. doi: 10.1016/j.neuroscience.2015.09.004. Epub 2015 Sep 4. Neuroscience. 2015. PMID: 26343295 Free PMC article.
Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.
Burgdorf J, Kroes RA, Zhang XL, Gross AL, Schmidt M, Weiss C, Disterhoft JF, Burch RM, Stanton PK, Moskal JR. Burgdorf J, et al. Among authors: kroes ra. Behav Brain Res. 2015 Nov 1;294:177-85. doi: 10.1016/j.bbr.2015.07.039. Epub 2015 Jul 22. Behav Brain Res. 2015. PMID: 26210936 Free PMC article.
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