Kronbach T - Search Results

1

Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6.

Kronbach T. Kronbach T. Methods Enzymol. 1991;206:509-17. doi: 10.1016/0076-6879(91)06120-r. Methods Enzymol. 1991. PMID: 1686064 No abstract available.

2

High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P-450 isozymes of human liver.

Kronbach T, Mathys D, Gut J, Catin T, Meyer UA. Kronbach T, et al. Anal Biochem. 1987 Apr;162(1):24-32. doi: 10.1016/0003-2697(87)90006-6. Anal Biochem. 1987. PMID: 3605590

3

Debrisoquine-type polymorphism of drug oxidation: purification from human liver of a cytochrome P450 isozyme with high activity for bufuralol hydroxylation.

Gut J, Gasser R, Dayer P, Kronbach T, Catin T, Meyer UA. Gut J, et al. Among authors: kronbach t. FEBS Lett. 1984 Aug 6;173(2):287-90. doi: 10.1016/0014-5793(84)80792-9. FEBS Lett. 1984. PMID: 6146537

4

Debrisoquine/sparteine-type polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol.

Gut J, Catin T, Dayer P, Kronbach T, Zanger U, Meyer UA. Gut J, et al. Among authors: kronbach t. J Biol Chem. 1986 Sep 5;261(25):11734-43. J Biol Chem. 1986. PMID: 3745165

5

Stereo- and regioselectivity of hepatic oxidation in man--effect of the debrisoquine/sparteine phenotype on bufuralol hydroxylation.

Dayer P, Leemann T, Küpfer A, Kronbach T, Meyer UA. Dayer P, et al. Among authors: kronbach t. Eur J Clin Pharmacol. 1986;31(3):313-8. doi: 10.1007/BF00981130. Eur J Clin Pharmacol. 1986. PMID: 2878813

6

Characterization of a common genetic defect of cytochrome P-450 function (debrisoquine-sparteine type polymorphism)--increased Michaelis is Constant (Km) and loss of stereoselectivity of bufuralol 1'-hydroxylation in poor metabolizers.

Dayer P, Gasser R, Gut J, Kronbach T, Robertz GM, Eichelbaum M, Meyer UA. Dayer P, et al. Among authors: kronbach t. Biochem Biophys Res Commun. 1984 Nov 30;125(1):374-80. doi: 10.1016/s0006-291x(84)80378-2. Biochem Biophys Res Commun. 1984. PMID: 6508804

7

Enzymatic basis of the debrisoquine/sparteine-type genetic polymorphism of drug oxidation. Characterization of bufuralol 1'-hydroxylation in liver microsomes of in vivo phenotyped carriers of the genetic deficiency.

Dayer P, Kronbach T, Eichelbaum M, Meyer UA. Dayer P, et al. Among authors: kronbach t. Biochem Pharmacol. 1987 Dec 1;36(23):4145-52. doi: 10.1016/0006-2952(87)90573-9. Biochem Pharmacol. 1987. PMID: 3689440

8

Assay of mephenytoin metabolism in human liver microsomes by high-performance liquid chromatography.

Meier UT, Kronbach T, Meyer UA. Meier UT, et al. Among authors: kronbach t. Anal Biochem. 1985 Dec;151(2):286-91. doi: 10.1016/0003-2697(85)90177-0. Anal Biochem. 1985. PMID: 4096368

9

A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1.

Kronbach T, Kemper B, Johnson EF. Kronbach T, et al. Biochemistry. 1991 Jun 25;30(25):6097-102. doi: 10.1021/bi00239a003. Biochemistry. 1991. PMID: 2059619

10

An inhibitory monoclonal antibody binds in close proximity to a determinant for substrate binding in cytochrome P450IIC5.

Kronbach T, Johnson EF. Kronbach T, et al. J Biol Chem. 1991 Apr 5;266(10):6215-20. J Biol Chem. 1991. PMID: 1706711

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