Kropshofer H - Search Results

1

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation.

Jawa V, Cousens LP, Awwad M, Wakshull E, Kropshofer H, De Groot AS. Jawa V, et al. Among authors: kropshofer h. Clin Immunol. 2013 Dec;149(3):534-55. doi: 10.1016/j.clim.2013.09.006. Epub 2013 Sep 25. Clin Immunol. 2013. PMID: 24263283 Free article. Review.

2

Perspectives on Subcutaneous Route of Administration as an Immunogenicity Risk Factor for Therapeutic Proteins.

Hamuro L, Kijanka G, Kinderman F, Kropshofer H, Bu DX, Zepeda M, Jawa V. Hamuro L, et al. Among authors: kropshofer h. J Pharm Sci. 2017 Oct;106(10):2946-2954. doi: 10.1016/j.xphs.2017.05.030. Epub 2017 May 31. J Pharm Sci. 2017. PMID: 28576695 Review.

3

Taking immunogenicity assessment of therapeutic proteins to the next level.

Büttel IC, Chamberlain P, Chowers Y, Ehmann F, Greinacher A, Jefferis R, Kramer D, Kropshofer H, Lloyd P, Lubiniecki A, Krause R, Mire-Sluis A, Platts-Mills T, Ragheb JA, Reipert BM, Schellekens H, Seitz R, Stas P, Subramanyam M, Thorpe R, Trouvin JH, Weise M, Windisch J, Schneider CK. Büttel IC, et al. Among authors: kropshofer h. Biologicals. 2011 Mar;39(2):100-9. doi: 10.1016/j.biologicals.2011.01.006. Epub 2011 Feb 24. Biologicals. 2011. PMID: 21353596

4

Evaluation of the immuno-stimulatory potential of stopper extractables and leachables by using dendritic cells as readout.

Mueller R, Karle A, Vogt A, Kropshofer H, Ross A, Maeder K, Mahler HC. Mueller R, et al. Among authors: kropshofer h. J Pharm Sci. 2009 Oct;98(10):3548-61. doi: 10.1002/jps.21672. J Pharm Sci. 2009. PMID: 19226629

5

Overview of cell-based tools for pre-clinical assessment of immunogenicity of biotherapeutics.

Kropshofer H, Singer T. Kropshofer H, et al. J Immunotoxicol. 2006 Sep 1;3(3):131-6. doi: 10.1080/15476910600845625. J Immunotoxicol. 2006. PMID: 18958693

6

The safety and side effects of monoclonal antibodies.

Hansel TT, Kropshofer H, Singer T, Mitchell JA, George AJ. Hansel TT, et al. Among authors: kropshofer h. Nat Rev Drug Discov. 2010 Apr;9(4):325-38. doi: 10.1038/nrd3003. Epub 2010 Mar 22. Nat Rev Drug Discov. 2010. PMID: 20305665 Review.

7

Clustering of MHC-peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains.

Vogt AB, Spindeldreher S, Kropshofer H. Vogt AB, et al. Among authors: kropshofer h. Immunol Rev. 2002 Nov;189:136-51. doi: 10.1034/j.1600-065x.2002.18912.x. Immunol Rev. 2002. PMID: 12445271 Review.

8

Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization.

Röhn TA, Boes M, Wolters D, Spindeldreher S, Müller B, Langen H, Ploegh H, Vogt AB, Kropshofer H. Röhn TA, et al. Among authors: kropshofer h. Nat Immunol. 2004 Sep;5(9):909-18. doi: 10.1038/ni1108. Epub 2004 Aug 22. Nat Immunol. 2004. PMID: 15322540

9

Melanoma cell necrosis facilitates transfer of specific sets of antigens onto MHC class II molecules of dendritic cells.

Röhn TA, Schadendorf D, Sun Y, Nguyen XD, Roeder D, Langen H, Vogt AB, Kropshofer H. Röhn TA, et al. Among authors: kropshofer h. Eur J Immunol. 2005 Oct;35(10):2826-39. doi: 10.1002/eji.200526299. Eur J Immunol. 2005. PMID: 16163671 Free article.

10

A novel strategy for the discovery of MHC class II-restricted tumor antigens: identification of a melanotransferrin helper T-cell epitope.

Röhn TA, Reitz A, Paschen A, Nguyen XD, Schadendorf D, Vogt AB, Kropshofer H. Röhn TA, et al. Among authors: kropshofer h. Cancer Res. 2005 Nov 1;65(21):10068-78. doi: 10.1158/0008-5472.CAN-05-1973. Cancer Res. 2005. PMID: 16267033

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