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CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris.
Abrams JR, Lebwohl MG, Guzzo CA, Jegasothy BV, Goldfarb MT, Goffe BS, Menter A, Lowe NJ, Krueger G, Brown MJ, Weiner RS, Birkhofer MJ, Warner GL, Berry KK, Linsley PS, Krueger JG, Ochs HD, Kelley SL, Kang S. Abrams JR, et al. Among authors: krueger jg, krueger g. J Clin Invest. 1999 May;103(9):1243-52. doi: 10.1172/JCI5857. J Clin Invest. 1999. PMID: 10225967 Free PMC article. Clinical Trial.
Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis.
Gottlieb A, Krueger JG, Bright R, Ling M, Lebwohl M, Kang S, Feldman S, Spellman M, Wittkowski K, Ochs HD, Jardieu P, Bauer R, White M, Dedrick R, Garovoy M. Gottlieb A, et al. Among authors: krueger jg. J Am Acad Dermatol. 2000 Mar;42(3):428-35. doi: 10.1016/s0190-9622(00)90214-7. J Am Acad Dermatol. 2000. PMID: 10688712
Two considerations for patients with psoriasis and their clinicians: what defines mild, moderate, and severe psoriasis? What constitutes a clinically significant improvement when treating psoriasis?
Krueger GG, Feldman SR, Camisa C, Duvic M, Elder JT, Gottlieb AB, Koo J, Krueger JG, Lebwohl M, Lowe N, Menter A, Morison WL, Prystowsky JH, Shupack JL, Taylor JR, Weinstein GD, Barton TL, Rolstad T, Day RM. Krueger GG, et al. Among authors: krueger jg. J Am Acad Dermatol. 2000 Aug;43(2 Pt 1):281-5. doi: 10.1067/mjd.2000.106374. J Am Acad Dermatol. 2000. PMID: 10906652
Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells.
Abrams JR, Kelley SL, Hayes E, Kikuchi T, Brown MJ, Kang S, Lebwohl MG, Guzzo CA, Jegasothy BV, Linsley PS, Krueger JG. Abrams JR, et al. Among authors: krueger jg. J Exp Med. 2000 Sep 4;192(5):681-94. doi: 10.1084/jem.192.5.681. J Exp Med. 2000. PMID: 10974034 Free PMC article.
Anti-CD4 monoclonal antibody treatment of moderate to severe psoriasis vulgaris: results of a pilot, multicenter, multiple-dose, placebo-controlled study.
Gottlieb AB, Lebwohl M, Shirin S, Sherr A, Gilleaudeau P, Singer G, Solodkina G, Grossman R, Gisoldi E, Phillips S, Neisler HM, Krueger JG. Gottlieb AB, et al. Among authors: krueger jg. J Am Acad Dermatol. 2000 Oct;43(4):595-604. doi: 10.1067/mjd.2000.107945. J Am Acad Dermatol. 2000. PMID: 11004613 Clinical Trial.
451 results