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Constitutively active ezrin increases membrane tension, slows migration, and impedes endothelial transmigration of lymphocytes in vivo in mice.
Liu Y, Belkina NV, Park C, Nambiar R, Loughhead SM, Patino-Lopez G, Ben-Aissa K, Hao JJ, Kruhlak MJ, Qi H, von Andrian UH, Kehrl JH, Tyska MJ, Shaw S. Liu Y, et al. Among authors: kruhlak mj. Blood. 2012 Jan 12;119(2):445-53. doi: 10.1182/blood-2011-07-368860. Epub 2011 Nov 21. Blood. 2012. PMID: 22106344 Free PMC article.
Activation of moesin, a protein that links actin cytoskeleton to the plasma membrane, occurs by phosphatidylinositol 4,5-bisphosphate (PIP2) binding sequentially to two sites and releasing an autoinhibitory linker.
Ben-Aissa K, Patino-Lopez G, Belkina NV, Maniti O, Rosales T, Hao JJ, Kruhlak MJ, Knutson JR, Picart C, Shaw S. Ben-Aissa K, et al. Among authors: kruhlak mj. J Biol Chem. 2012 May 11;287(20):16311-23. doi: 10.1074/jbc.M111.304881. Epub 2012 Mar 20. J Biol Chem. 2012. PMID: 22433855 Free PMC article.
110 results