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Polycomb group proteins in cancer: multifaceted functions and strategies for modulation.

Wang S, C Ordonez-Rubiano S, Dhiman A, Jiao G, Strohmier BP, Krusemark CJ, Dykhuizen EC. Wang S, et al. Among authors: krusemark cj. NAR Cancer. 2021 Oct 4;3(4):zcab039. doi: 10.1093/narcan/zcab039. eCollection 2021 Dec. NAR Cancer. 2021. PMID: 34617019 Free PMC article.

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A Potent, Selective CBX2 Chromodomain Ligand and Its Cellular Activity During Prostate Cancer Neuroendocrine Differentiation.

Wang S, Alpsoy A, Sood S, Ordonez-Rubiano SC, Dhiman A, Sun Y, Jiao G, Krusemark CJ, Dykhuizen EC. Wang S, et al. Among authors: krusemark cj. Chembiochem. 2021 Jul 1;22(13):2335-2344. doi: 10.1002/cbic.202100118. Epub 2021 May 28. Chembiochem. 2021. PMID: 33950564 Free PMC article.

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Selection of DNA-Encoded Libraries to Protein Targets within and on Living Cells.

Cai B, Kim D, Akhand S, Sun Y, Cassell RJ, Alpsoy A, Dykhuizen EC, Van Rijn RM, Wendt MK, Krusemark CJ. Cai B, et al. Among authors: krusemark cj. J Am Chem Soc. 2019 Oct 30;141(43):17057-17061. doi: 10.1021/jacs.9b08085. Epub 2019 Oct 22. J Am Chem Soc. 2019. PMID: 31613623 Free PMC article.

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Optimization of Ligands Using Focused DNA-Encoded Libraries To Develop a Selective, Cell-Permeable CBX8 Chromodomain Inhibitor.

Wang S, Denton KE, Hobbs KF, Weaver T, McFarlane JMB, Connelly KE, Gignac MC, Milosevich N, Hof F, Paci I, Musselman CA, Dykhuizen EC, Krusemark CJ. Wang S, et al. Among authors: krusemark cj. ACS Chem Biol. 2020 Jan 17;15(1):112-131. doi: 10.1021/acschembio.9b00654. Epub 2019 Dec 12. ACS Chem Biol. 2020. PMID: 31755685 Free PMC article.

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Directed Chemical Evolution with an Outsized Genetic Code.

Krusemark CJ, Tilmans NP, Brown PO, Harbury PB. Krusemark CJ, et al. PLoS One. 2016 Aug 10;11(8):e0154765. doi: 10.1371/journal.pone.0154765. eCollection 2016. PLoS One. 2016. PMID: 27508294 Free PMC article.

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Sensing Enzymatic Activity by Exposure and Selection of DNA-Encoded Probes.

Jetson RR, Krusemark CJ. Jetson RR, et al. Among authors: krusemark cj. Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9562-6. doi: 10.1002/anie.201603387. Epub 2016 Jun 29. Angew Chem Int Ed Engl. 2016. PMID: 27355201 Free PMC article.

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Application of a Substrate-Mediated Selection with c-Src Tyrosine Kinase to a DNA-Encoded Chemical Library.

Kim D, Sun Y, Xie D, Denton KE, Chen H, Lin H, Wendt MK, Post CB, Krusemark CJ. Kim D, et al. Among authors: krusemark cj. Molecules. 2019 Jul 30;24(15):2764. doi: 10.3390/molecules24152764. Molecules. 2019. PMID: 31366048 Free PMC article.

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Multiplexed Small-Molecule-Ligand Binding Assays by Affinity Labeling and DNA Sequence Analysis.

Cai B, Krusemark CJ. Cai B, et al. Among authors: krusemark cj. Angew Chem Int Ed Engl. 2022 Jan 17;61(3):e202113515. doi: 10.1002/anie.202113515. Epub 2021 Dec 3. Angew Chem Int Ed Engl. 2022. PMID: 34758183

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Spleen Tyrosine Kinase-Mediated Autophagy Is Required for Epithelial-Mesenchymal Plasticity and Metastasis in Breast Cancer.

Shinde A, Hardy SD, Kim D, Akhand SS, Jolly MK, Wang WH, Anderson JC, Khodadadi RB, Brown WS, George JT, Liu S, Wan J, Levine H, Willey CD, Krusemark CJ, Geahlen RL, Wendt MK. Shinde A, et al. Among authors: krusemark cj. Cancer Res. 2019 Apr 15;79(8):1831-1843. doi: 10.1158/0008-5472.CAN-18-2636. Epub 2019 Feb 7. Cancer Res. 2019. PMID: 30733195 Free PMC article.

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Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8.

Denton KE, Wang S, Gignac MC, Milosevich N, Hof F, Dykhuizen EC, Krusemark CJ. Denton KE, et al. Among authors: krusemark cj. SLAS Discov. 2018 Jun;23(5):417-428. doi: 10.1177/2472555217750871. Epub 2018 Jan 8. SLAS Discov. 2018. PMID: 29309209 Free PMC article.

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