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Perspective of cyclin-dependent kinase 9 (CDK9) as a drug target.
Krystof V, Baumli S, Fürst R. Krystof V, et al. Curr Pharm Des. 2012;18(20):2883-90. doi: 10.2174/138161212800672750. Curr Pharm Des. 2012. PMID: 22571657 Free PMC article. Review.
Synthesis and biological activity of olomoucine II.
Krystof V, Lenobel R, Havlícek L, Kuzma M, Strnad M. Krystof V, et al. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3283-6. doi: 10.1016/s0960-894x(02)00693-5. Bioorg Med Chem Lett. 2002. PMID: 12392733
Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors.
Moravcová D, Krystof V, Havlícek L, Moravec J, Lenobel R, Strnad M. Moravcová D, et al. Among authors: krystof v. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2989-92. doi: 10.1016/s0960-894x(03)00631-0. Bioorg Med Chem Lett. 2003. PMID: 12941318
2,6,8,9-tetrasubstituted purines as new CDK1 inhibitors.
Moravec J, Krystof V, Hanus J, Havlícek L, Moravcová D, Fuksová K, Kuzma M, Lenobel R, Otyepka M, Strnad M. Moravec J, et al. Among authors: krystof v. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2993-6. doi: 10.1016/s0960-894x(03)00632-2. Bioorg Med Chem Lett. 2003. PMID: 12941319
8-Azapurines as new inhibitors of cyclin-dependent kinases.
Havlicek L, Fuksova K, Krystof V, Orsag M, Vojtesek B, Strnad M. Havlicek L, et al. Among authors: krystof v. Bioorg Med Chem. 2005 Sep 15;13(18):5399-407. doi: 10.1016/j.bmc.2005.06.007. Bioorg Med Chem. 2005. PMID: 15993080
Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells.
Dolezal K, Popa I, Krystof V, Spíchal L, Fojtíková M, Holub J, Lenobel R, Schmülling T, Strnad M. Dolezal K, et al. Among authors: krystof v. Bioorg Med Chem. 2006 Feb 1;14(3):875-84. doi: 10.1016/j.bmc.2005.09.004. Epub 2005 Oct 7. Bioorg Med Chem. 2006. PMID: 16214355
Zinc(II) complexes with potent cyclin-dependent kinase inhibitors derived from 6-benzylaminopurine: synthesis, characterization, X-ray structures and biological activity.
Trávnícek Z, Krystof V, Sipl M. Trávnícek Z, et al. Among authors: krystof v. J Inorg Biochem. 2006 Feb;100(2):214-25. doi: 10.1016/j.jinorgbio.2005.07.006. Epub 2006 Jan 4. J Inorg Biochem. 2006. PMID: 16386795
Tumour suppressor PTEN regulates cell cycle and protein kinase B/Akt pathway in breast cancer cells.
Hlobilkova A, Knillova J, Svachova M, Skypalova P, Krystof V, Kolar Z. Hlobilkova A, et al. Among authors: krystof v. Anticancer Res. 2006 Mar-Apr;26(2A):1015-22. Anticancer Res. 2006. PMID: 16619501
4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Krystof V, Cankar P, Frysová I, Slouka J, Kontopidis G, Dzubák P, Hajdúch M, Srovnal J, de Azevedo WF Jr, Orság M, Paprskárová M, Rolcík J, Látr A, Fischer PM, Strnad M. Krystof V, et al. J Med Chem. 2006 Nov 2;49(22):6500-9. doi: 10.1021/jm0605740. J Med Chem. 2006. PMID: 17064068
Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases.
Spíchal L, Krystof V, Paprskárová M, Lenobel R, Styskala J, Binarová P, Cenklová V, De Veylder L, Inzé D, Kontopidis G, Fischer PM, Schmülling T, Strnad M. Spíchal L, et al. Among authors: krystof v. J Biol Chem. 2007 May 11;282(19):14356-63. doi: 10.1074/jbc.M609750200. Epub 2007 Mar 5. J Biol Chem. 2007. PMID: 17339323
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