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Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma.
Choi BD, Kuan CT, Cai M, Archer GE, Mitchell DA, Gedeon PC, Sanchez-Perez L, Pastan I, Bigner DD, Sampson JH. Choi BD, et al. Among authors: kuan ct. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):270-5. doi: 10.1073/pnas.1219817110. Epub 2012 Dec 17. Proc Natl Acad Sci U S A. 2013. PMID: 23248284 Free PMC article.
Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas.
Kato Y, Vaidyanathan G, Kaneko MK, Mishima K, Srivastava N, Chandramohan V, Pegram C, Keir ST, Kuan CT, Bigner DD, Zalutsky MR. Kato Y, et al. Nucl Med Biol. 2010 Oct;37(7):785-94. doi: 10.1016/j.nucmedbio.2010.03.010. Nucl Med Biol. 2010. PMID: 20870153 Free PMC article.
Radioimmunotargeting of malignant glioma by monoclonal antibody D2C7 reactive against both wild-type and variant III mutant epidermal growth factor receptors.
Zalutsky MR, Boskovitz A, Kuan CT, Pegram CN, Ayriss J, Wikstrand CJ, Buckley AF, Lipp ES, Herndon JE 2nd, McLendon RE, Bigner DD. Zalutsky MR, et al. Nucl Med Biol. 2012 Jan;39(1):23-34. doi: 10.1016/j.nucmedbio.2011.06.005. Epub 2011 Sep 29. Nucl Med Biol. 2012. PMID: 21958852 Free PMC article.
Detection of amino-terminal extracellular domain of somatostatin receptor 2 by specific monoclonal antibodies and quantification of receptor density in medulloblastoma.
Kuan CT, Wikstrand CJ, McLendon RE, Zalutsky MR, Kumar U, Bigner DD. Kuan CT, et al. Hybridoma (Larchmt). 2009 Dec;28(6):389-403. doi: 10.1089/hyb.2009.0049. Hybridoma (Larchmt). 2009. PMID: 20025498 Free PMC article.
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase--a key enzyme in lacto-neolacto ganglioside synthesis.
Kuan CT, Chang J, Mansson JE, Li J, Pegram C, Fredman P, McLendon RE, Bigner DD. Kuan CT, et al. BMC Dev Biol. 2010 Nov 18;10:114. doi: 10.1186/1471-213X-10-114. BMC Dev Biol. 2010. PMID: 21087515 Free PMC article.
Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas.
Piao H, Kuan CT, Chandramohan V, Keir ST, Pegram CN, Bao X, Månsson JE, Pastan IH, Bigner DD. Piao H, et al. Among authors: kuan ct. MAbs. 2013 Sep-Oct;5(5):748-62. doi: 10.4161/mabs.25860. Epub 2013 Jul 25. MAbs. 2013. PMID: 23924792 Free PMC article.
Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas.
Kuan CT, Wakiya K, Keir ST, Li J, Herndon JE 2nd, Pastan I, Bigner DD. Kuan CT, et al. Int J Cancer. 2011 Jul 1;129(1):111-21. doi: 10.1002/ijc.25645. Epub 2010 Nov 3. Int J Cancer. 2011. PMID: 20824708 Free PMC article.
MRP3: a molecular target for human glioblastoma multiforme immunotherapy.
Kuan CT, Wakiya K, Herndon JE 2nd, Lipp ES, Pegram CN, Riggins GJ, Rasheed A, Szafranski SE, McLendon RE, Wikstrand CJ, Bigner DD. Kuan CT, et al. BMC Cancer. 2010 Sep 1;10:468. doi: 10.1186/1471-2407-10-468. BMC Cancer. 2010. PMID: 20809959 Free PMC article.
GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice.
Kato Y, Kuan CT, Chang J, Kaneko MK, Ayriss J, Piao H, Chandramohan V, Pegram C, McLendon RE, Fredman P, Månsson JE, Bigner DD. Kato Y, et al. Biochem Biophys Res Commun. 2010 Jan 1;391(1):750-5. doi: 10.1016/j.bbrc.2009.11.132. Epub 2009 Nov 26. Biochem Biophys Res Commun. 2010. PMID: 19944071 Free PMC article.
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