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The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Wiedmann RM, von Schwarzenberg K, Palamidessi A, Schreiner L, Kubisch R, Liebl J, Schempp C, Trauner D, Vereb G, Zahler S, Wagner E, Müller R, Scita G, Vollmar AM. Wiedmann RM, et al. Among authors: kubisch r. Cancer Res. 2012 Nov 15;72(22):5976-87. doi: 10.1158/0008-5472.CAN-12-1772. Epub 2012 Sep 17. Cancer Res. 2012. PMID: 22986742
Pretubulysin: a new option for the treatment of metastatic cancer.
Braig S, Wiedmann RM, Liebl J, Singer M, Kubisch R, Schreiner L, Abhari BA, Wagner E, Kazmaier U, Fulda S, Vollmar AM. Braig S, et al. Among authors: kubisch r. Cell Death Dis. 2014 Jan 16;5(1):e1001. doi: 10.1038/cddis.2013.510. Cell Death Dis. 2014. PMID: 24434509 Free PMC article.
Targeting the actin cytoskeleton: selective antitumor action via trapping PKCɛ.
Foerster F, Braig S, Moser C, Kubisch R, Busse J, Wagner E, Schmoeckel E, Mayr D, Schmitt S, Huettel S, Zischka H, Mueller R, Vollmar AM. Foerster F, et al. Among authors: kubisch r. Cell Death Dis. 2014 Aug 28;5(8):e1398. doi: 10.1038/cddis.2014.363. Cell Death Dis. 2014. PMID: 25165884 Free PMC article.
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