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Choline acetyltransferase-expressing T cells are required to control chronic viral infection.
Cox MA, Duncan GS, Lin GHY, Steinberg BE, Yu LX, Brenner D, Buckler LN, Elia AJ, Wakeham AC, Nieman B, Dominguez-Brauer C, Elford AR, Gill KT, Kubli SP, Haight J, Berger T, Ohashi PS, Tracey KJ, Olofsson PS, Mak TW. Cox MA, et al. Among authors: kubli sp. Science. 2019 Feb 8;363(6427):639-644. doi: 10.1126/science.aau9072. Science. 2019. PMID: 30733420 Free PMC article.
AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer.
Kubli SP, Bassi C, Roux C, Wakeham A, Göbl C, Zhou W, Jafari SM, Snow B, Jones L, Palomero L, Thu KL, Cassetta L, Soong D, Berger T, Ramachandran P, Baniasadi SP, Duncan G, Lindzen M, Yarden Y, Herranz C, Lazaro C, Chu MF, Haight J, Tinto P, Silvester J, Cescon DW, Petit A, Pettersson S, Pollard JW, Mak TW, Pujana MA, Cappello P, Gorrini C. Kubli SP, et al. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3604-3613. doi: 10.1073/pnas.1815126116. Epub 2019 Feb 7. Proc Natl Acad Sci U S A. 2019. PMID: 30733286 Free PMC article.
Fcmr regulates mononuclear phagocyte control of anti-tumor immunity.
Kubli SP, Vornholz L, Duncan G, Zhou W, Ramachandran P, Fortin J, Cox M, Han S, Nechanitzky R, Nechanitzky D, Snow BE, Jones L, Li WY, Haight J, Wakeham A, Bray MR, Mak TW. Kubli SP, et al. Nat Commun. 2019 Jun 18;10(1):2678. doi: 10.1038/s41467-019-10619-w. Nat Commun. 2019. PMID: 31213601 Free PMC article.
An aberrant STAT pathway is central to COVID-19.
Matsuyama T, Kubli SP, Yoshinaga SK, Pfeffer K, Mak TW. Matsuyama T, et al. Among authors: kubli sp. Cell Death Differ. 2020 Dec;27(12):3209-3225. doi: 10.1038/s41418-020-00633-7. Epub 2020 Oct 9. Cell Death Differ. 2020. PMID: 33037393 Free PMC article. Review.
Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab.
Watson GA, Sanz-Garcia E, Zhang WJ, Liu ZA, Yang SC, Wang B, Liu S, Kubli S, Berman H, Pfister T, Genta S, Spreafico A, Hansen AR, Bedard PL, Lheureux S, Abdul Razak A, Cescon D, Butler MO, Xu W, Mak TW, Siu LL, Chen E. Watson GA, et al. J Immunother Cancer. 2022 Jun;10(6):e004378. doi: 10.1136/jitc-2021-004378. J Immunother Cancer. 2022. PMID: 35705312 Free PMC article.
Identification of an Optimized Receptor-Binding Domain Subunit Vaccine against SARS-CoV-2.
Yu H, Worrall LJ, Berger T, Petric M, Lin BH, Vuckovic M, Robb CS, Le Q, Kenward C, Dai C, Wakeham A, Liu S, Snow B, Tobin C, Budylowski P, Guvenc F, You-Ten A, Haight J, Silvester J, Singh RP, Ahn SK, Sultana A, Poon B, Lam J, Christie-Holmes N, Ostrowski M, Gray-Owen SD, Kubli S, Mak T, Strynadka NCJ, Brunham RC. Yu H, et al. J Immunol. 2023 Sep 15;211(6):981-993. doi: 10.4049/jimmunol.2300282. J Immunol. 2023. PMID: 37493438
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