Synthesis of a new reactivator of tabun-inhibited acetylcholinesterase

Bioorg Med Chem Lett. 2003 Oct 20;13(20):3545-7. doi: 10.1016/s0960-894x(03)00751-0.

Abstract

Synthesis of a new asymmetric bisquaternary reactivator of tabun-inhibited acetylcholinesterase-1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium) butane dibromide is described. Reactivation potency of this oxime is compared to the currently used reactivators-pralidoxime, obidoxime and H-oxime HI-6.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cholinesterase Inhibitors / pharmacology*
  • Enzyme Reactivators / chemical synthesis*
  • Kinetics
  • Organophosphates / pharmacology*

Substances

  • Cholinesterase Inhibitors
  • Enzyme Reactivators
  • Organophosphates
  • tabun