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Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells.
Iizuka-Ohashi M, Watanabe M, Sukeno M, Morita M, Hoang NTH, Kuchimaru T, Kizaka-Kondoh S, Sowa Y, Sakaguchi K, Taguchi T, Sakai T. Iizuka-Ohashi M, et al. Among authors: kuchimaru t. Oncotarget. 2018 Apr 13;9(28):19597-19612. doi: 10.18632/oncotarget.24696. eCollection 2018 Apr 13. Oncotarget. 2018. PMID: 29731968 Free PMC article.
Detection of the onset of ischemia and carcinogenesis by hypoxia-inducible transcription factor-based in vivo bioluminescence imaging.
Kadonosono T, Kuchimaru T, Yamada S, Takahashi Y, Murakami A, Tani T, Watanabe H, Tanaka T, Hirota K, Inoue M, Tsukamoto T, Toyoda T, Urano K, Machida K, Eto T, Ogura T, Tsutsumi H, Ito M, Hiraoka M, Kondoh G, Kizaka-Kondoh S. Kadonosono T, et al. Among authors: kuchimaru t. PLoS One. 2011;6(11):e26640. doi: 10.1371/journal.pone.0026640. Epub 2011 Nov 10. PLoS One. 2011. PMID: 22102864 Free PMC article.
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.
Nishida C, Kusubata K, Tashiro Y, Gritli I, Sato A, Ohki-Koizumi M, Morita Y, Nagano M, Sakamoto T, Koshikawa N, Kuchimaru T, Kizaka-Kondoh S, Seiki M, Nakauchi H, Heissig B, Hattori K. Nishida C, et al. Among authors: kuchimaru t. Blood. 2012 Jun 7;119(23):5405-16. doi: 10.1182/blood-2011-11-390849. Epub 2012 Apr 27. Blood. 2012. PMID: 22544701 Free article.
A fluorescent protein scaffold for presenting structurally constrained peptides provides an effective screening system to identify high affinity target-binding peptides.
Kadonosono T, Yabe E, Furuta T, Yamano A, Tsubaki T, Sekine T, Kuchimaru T, Sakurai M, Kizaka-Kondoh S. Kadonosono T, et al. Among authors: kuchimaru t. PLoS One. 2014 Aug 1;9(8):e103397. doi: 10.1371/journal.pone.0103397. eCollection 2014. PLoS One. 2014. PMID: 25084350 Free PMC article.
40 results