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Systems Medicine in Pharmaceutical Research and Development.
Kuepfer L, Schuppert A. Kuepfer L, et al. Methods Mol Biol. 2016;1386:87-104. doi: 10.1007/978-1-4939-3283-2_6. Methods Mol Biol. 2016. PMID: 26677181 Review.
Systematic evaluation of objective functions for predicting intracellular fluxes in Escherichia coli.
Schuetz R, Kuepfer L, Sauer U. Schuetz R, et al. Among authors: kuepfer l. Mol Syst Biol. 2007;3:119. doi: 10.1038/msb4100162. Epub 2007 Jul 10. Mol Syst Biol. 2007. PMID: 17625511 Free PMC article.
A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.
Eissing T, Kuepfer L, Becker C, Block M, Coboeken K, Gaub T, Goerlitz L, Jaeger J, Loosen R, Ludewig B, Meyer M, Niederalt C, Sevestre M, Siegmund HU, Solodenko J, Thelen K, Telle U, Weiss W, Wendl T, Willmann S, Lippert J. Eissing T, et al. Among authors: kuepfer l. Front Physiol. 2011 Feb 24;2:4. doi: 10.3389/fphys.2011.00004. eCollection 2011. Front Physiol. 2011. PMID: 21483730 Free PMC article.
Multiscale mechanistic modeling in pharmaceutical research and development.
Kuepfer L, Lippert J, Eissing T. Kuepfer L, et al. Adv Exp Med Biol. 2012;736:543-61. doi: 10.1007/978-1-4419-7210-1_32. Adv Exp Med Biol. 2012. PMID: 22161351 Review.
Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling.
Meyer M, Schneckener S, Ludewig B, Kuepfer L, Lippert J. Meyer M, et al. Among authors: kuepfer l. Drug Metab Dispos. 2012 May;40(5):892-901. doi: 10.1124/dmd.111.043174. Epub 2012 Jan 31. Drug Metab Dispos. 2012. PMID: 22293118
Integrating cellular metabolism into a multiscale whole-body model.
Krauss M, Schaller S, Borchers S, Findeisen R, Lippert J, Kuepfer L. Krauss M, et al. Among authors: kuepfer l. PLoS Comput Biol. 2012;8(10):e1002750. doi: 10.1371/journal.pcbi.1002750. Epub 2012 Oct 25. PLoS Comput Biol. 2012. PMID: 23133351 Free PMC article.
A mechanistic, model-based approach to safety assessment in clinical development.
Lippert J, Brosch M, von Kampen O, Meyer M, Siegmund HU, Schafmayer C, Becker T, Laffert B, Görlitz L, Schreiber S, Neuvonen PJ, Niemi M, Hampe J, Kuepfer L. Lippert J, et al. Among authors: kuepfer l. CPT Pharmacometrics Syst Pharmacol. 2012 Nov 7;1(11):e13. doi: 10.1038/psp.2012.14. CPT Pharmacometrics Syst Pharmacol. 2012. PMID: 23835795 Free PMC article.
Spatio-temporal simulation of first pass drug perfusion in the liver.
Schwen LO, Krauss M, Niederalt C, Gremse F, Kiessling F, Schenk A, Preusser T, Kuepfer L. Schwen LO, et al. Among authors: kuepfer l. PLoS Comput Biol. 2014 Mar 13;10(3):e1003499. doi: 10.1371/journal.pcbi.1003499. eCollection 2014 Mar. PLoS Comput Biol. 2014. PMID: 24625393 Free PMC article.
Enabling multiscale modeling in systems medicine.
Wolkenhauer O, Auffray C, Brass O, Clairambault J, Deutsch A, Drasdo D, Gervasio F, Preziosi L, Maini P, Marciniak-Czochra A, Kossow C, Kuepfer L, Rateitschak K, Ramis-Conde I, Ribba B, Schuppert A, Smallwood R, Stamatakos G, Winter F, Byrne H. Wolkenhauer O, et al. Among authors: kuepfer l. Genome Med. 2014 Mar 21;6(3):21. doi: 10.1186/gm538. eCollection 2014. Genome Med. 2014. PMID: 25031615 Free PMC article. No abstract available.
Stoichiometric modelling of microbial metabolism.
Kuepfer L. Kuepfer L. Methods Mol Biol. 2014;1191:3-18. doi: 10.1007/978-1-4939-1170-7_1. Methods Mol Biol. 2014. PMID: 25178781
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