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Blinatumomab: a historical perspective.
Nagorsen D, Kufer P, Baeuerle PA, Bargou R. Nagorsen D, et al. Among authors: kufer p. Pharmacol Ther. 2012 Dec;136(3):334-42. doi: 10.1016/j.pharmthera.2012.07.013. Epub 2012 Aug 24. Pharmacol Ther. 2012. PMID: 22940266 Review.
Biologic properties of a bispecific single-chain antibody directed against 17-1A (EpCAM) and CD3: tumor cell-dependent T cell stimulation and cytotoxic activity.
Mack M, Gruber R, Schmidt S, Riethmüller G, Kufer P. Mack M, et al. Among authors: kufer p. J Immunol. 1997 Apr 15;158(8):3965-70. J Immunol. 1997. PMID: 9103467
Construction and biological activity of a recombinant bispecific single-chain antibody designed for therapy of minimal residual colorectal cancer.
Kufer P, Mack M, Gruber R, Lutterbüse R, Zettl F, Riethmüller G. Kufer P, et al. Cancer Immunol Immunother. 1997 Nov-Dec;45(3-4):193-7. doi: 10.1007/s002620050431. Cancer Immunol Immunother. 1997. PMID: 9435872
Bispecific single-chain antibodies as effective tools for eliminating epithelial cancer cells from human stem cell preparations by redirected cell cytotoxicity.
Maletz K, Kufer P, Mack M, Raum T, Pantel K, Riethmüller G, Gruber R. Maletz K, et al. Among authors: kufer p. Int J Cancer. 2001 Aug 1;93(3):409-16. doi: 10.1002/ijc.1348. Int J Cancer. 2001. PMID: 11433407
T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3- bispecific single-chain antibody construct.
Dreier T, Baeuerle PA, Fichtner I, Grün M, Schlereth B, Lorenczewski G, Kufer P, Lutterbüse R, Riethmüller G, Gjorstrup P, Bargou RC. Dreier T, et al. Among authors: kufer p. J Immunol. 2003 Apr 15;170(8):4397-402. doi: 10.4049/jimmunol.170.8.4397. J Immunol. 2003. PMID: 12682277
Bispecific antibodies for polyclonal T-cell engagement.
Baeuerle PA, Kufer P, Lutterbüse R. Baeuerle PA, et al. Among authors: kufer p. Curr Opin Mol Ther. 2003 Aug;5(4):413-9. Curr Opin Mol Ther. 2003. PMID: 14513685 Review.
Epithelial tight junction proteins as potential antibody targets for pancarcinoma therapy.
Offner S, Hekele A, Teichmann U, Weinberger S, Gross S, Kufer P, Itin C, Baeuerle PA, Kohleisen B. Offner S, et al. Among authors: kufer p. Cancer Immunol Immunother. 2005 May;54(5):431-45. doi: 10.1007/s00262-004-0613-x. Epub 2004 Oct 16. Cancer Immunol Immunother. 2005. PMID: 15750830
Eradication of tumors from a human colon cancer cell line and from ovarian cancer metastases in immunodeficient mice by a single-chain Ep-CAM-/CD3-bispecific antibody construct.
Schlereth B, Fichtner I, Lorenczewski G, Kleindienst P, Brischwein K, da Silva A, Kufer P, Lutterbuese R, Junghahn I, Kasimir-Bauer S, Wimberger P, Kimmig R, Baeuerle PA. Schlereth B, et al. Among authors: kufer p. Cancer Res. 2005 Apr 1;65(7):2882-9. doi: 10.1158/0008-5472.CAN-04-2637. Cancer Res. 2005. PMID: 15805290
T-cell activation and B-cell depletion in chimpanzees treated with a bispecific anti-CD19/anti-CD3 single-chain antibody construct.
Schlereth B, Quadt C, Dreier T, Kufer P, Lorenczewski G, Prang N, Brandl C, Lippold S, Cobb K, Brasky K, Leo E, Bargou R, Murthy K, Baeuerle PA. Schlereth B, et al. Among authors: kufer p. Cancer Immunol Immunother. 2006 May;55(5):503-14. doi: 10.1007/s00262-005-0001-1. Epub 2005 Jul 20. Cancer Immunol Immunother. 2006. PMID: 16032400
MT110: a novel bispecific single-chain antibody construct with high efficacy in eradicating established tumors.
Brischwein K, Schlereth B, Guller B, Steiger C, Wolf A, Lutterbuese R, Offner S, Locher M, Urbig T, Raum T, Kleindienst P, Wimberger P, Kimmig R, Fichtner I, Kufer P, Hofmeister R, da Silva AJ, Baeuerle PA. Brischwein K, et al. Among authors: kufer p. Mol Immunol. 2006 Mar;43(8):1129-43. doi: 10.1016/j.molimm.2005.07.034. Epub 2005 Sep 1. Mol Immunol. 2006. PMID: 16139892
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