Kuhn D - Search Results

1

Detailed structure-activity relationship of indolecarboxamides as H4 receptor ligands.

Engelhardt H, de Esch IJ, Kuhn D, Smits RA, Zuiderveld OP, Dobler J, Mayer M, Lips S, Arnhof H, Scharn D, Haaksma EE, Leurs R. Engelhardt H, et al. Among authors: kuhn d. Eur J Med Chem. 2012 Aug;54:660-8. doi: 10.1016/j.ejmech.2012.06.016. Epub 2012 Jun 18. Eur J Med Chem. 2012. PMID: 22749391

2

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.

Weber A, Casini A, Heine A, Kuhn D, Supuran CT, Scozzafava A, Klebe G. Weber A, et al. Among authors: kuhn d. J Med Chem. 2004 Jan 29;47(3):550-7. doi: 10.1021/jm030912m. J Med Chem. 2004. PMID: 14736236

3

Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models.

Buchstaller HP, Anlauf U, Dorsch D, Kögler S, Kuhn D, Lehmann M, Leuthner B, Lodholz S, Musil D, Radtki D, Rettig C, Ritzert C, Rohdich F, Schneider R, Wegener A, Weigt S, Wilkinson K, Esdar C. Buchstaller HP, et al. Among authors: kuhn d. J Med Chem. 2021 Jul 22;64(14):10371-10392. doi: 10.1021/acs.jmedchem.1c00800. Epub 2021 Jul 13. J Med Chem. 2021. PMID: 34255518

4

Discovery and Optimization of 2-Arylquinazolin-4-ones into a Potent and Selective Tankyrase Inhibitor Modulating Wnt Pathway Activity.

Buchstaller HP, Anlauf U, Dorsch D, Kuhn D, Lehmann M, Leuthner B, Musil D, Radtki D, Ritzert C, Rohdich F, Schneider R, Esdar C. Buchstaller HP, et al. Among authors: kuhn d. J Med Chem. 2019 Sep 12;62(17):7897-7909. doi: 10.1021/acs.jmedchem.9b00656. Epub 2019 Aug 20. J Med Chem. 2019. PMID: 31381853

5

A new method to detect related function among proteins independent of sequence and fold homology.

Schmitt S, Kuhn D, Klebe G. Schmitt S, et al. Among authors: kuhn d. J Mol Biol. 2002 Oct 18;323(2):387-406. doi: 10.1016/s0022-2836(02)00811-2. J Mol Biol. 2002. PMID: 12381328

6

Kuhn D, Weskamp N, Schmitt S, Hüllermeier E, Klebe G. Kuhn D, et al. J Mol Biol. 2006 Jun 16;359(4):1023-44. doi: 10.1016/j.jmb.2006.04.024. Epub 2006 Apr 25. J Mol Biol. 2006. PMID: 16697007 Free PMC article.

7

Functional classification of protein kinase binding sites using Cavbase.

Kuhn D, Weskamp N, Hüllermeier E, Klebe G. Kuhn D, et al. ChemMedChem. 2007 Oct;2(10):1432-47. doi: 10.1002/cmdc.200700075. ChemMedChem. 2007. PMID: 17694525

8

Multiple graph alignment for the structural analysis of protein active sites.

Weskamp N, Hüllermeier E, Kuhn D, Klebe G. Weskamp N, et al. Among authors: kuhn d. IEEE/ACM Trans Comput Biol Bioinform. 2007 Apr-Jun;4(2):310-20. doi: 10.1109/tcbb.2007.358301. IEEE/ACM Trans Comput Biol Bioinform. 2007. PMID: 17473323

9

Efficient similarity search in protein structure databases by k-clique hashing.

Weskamp N, Kuhn D, Hüllermeier E, Klebe G. Weskamp N, et al. Among authors: kuhn d. Bioinformatics. 2004 Jul 10;20(10):1522-6. doi: 10.1093/bioinformatics/bth113. Bioinformatics. 2004. PMID: 15231546

10

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors.

Al-Gharabli SI, Shah ST, Weik S, Schmidt MF, Mesters JR, Kuhn D, Klebe G, Hilgenfeld R, Rademann J. Al-Gharabli SI, et al. Among authors: kuhn d. Chembiochem. 2006 Jul;7(7):1048-55. doi: 10.1002/cbic.200500533. Chembiochem. 2006. PMID: 16688706 Free PMC article.

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