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CTLA-4: new insights into its biological function and use in tumor immunotherapy.
Egen JG, Kuhns MS, Allison JP. Egen JG, et al. Among authors: kuhns ms. Nat Immunol. 2002 Jul;3(7):611-8. doi: 10.1038/ni0702-611. Nat Immunol. 2002. PMID: 12087419 Review.
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses.
Chambers CA, Kuhns MS, Allison JP. Chambers CA, et al. Among authors: kuhns ms. Proc Natl Acad Sci U S A. 1999 Jul 20;96(15):8603-8. doi: 10.1073/pnas.96.15.8603. Proc Natl Acad Sci U S A. 1999. PMID: 10411922 Free PMC article.
Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates the size, reactivity, and function of a primed pool of CD4+ T cells.
Kuhns MS, Epshteyn V, Sobel RA, Allison JP. Kuhns MS, et al. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12711-6. doi: 10.1073/pnas.220423597. Proc Natl Acad Sci U S A. 2000. PMID: 11050166 Free PMC article.
CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy.
Chambers CA, Kuhns MS, Egen JG, Allison JP. Chambers CA, et al. Among authors: kuhns ms. Annu Rev Immunol. 2001;19:565-94. doi: 10.1146/annurev.immunol.19.1.565. Annu Rev Immunol. 2001. PMID: 11244047 Review.
T cells use two directionally distinct pathways for cytokine secretion.
Huse M, Lillemeier BF, Kuhns MS, Chen DS, Davis MM. Huse M, et al. Among authors: kuhns ms. Nat Immunol. 2006 Mar;7(3):247-55. doi: 10.1038/ni1304. Epub 2006 Jan 29. Nat Immunol. 2006. PMID: 16444260
Deconstructing the form and function of the TCR/CD3 complex.
Kuhns MS, Davis MM, Garcia KC. Kuhns MS, et al. Immunity. 2006 Feb;24(2):133-9. doi: 10.1016/j.immuni.2006.01.006. Immunity. 2006. PMID: 16473826 Review.
Disruption of extracellular interactions impairs T cell receptor-CD3 complex stability and signaling.
Kuhns MS, Davis MM. Kuhns MS, et al. Immunity. 2007 Mar;26(3):357-69. doi: 10.1016/j.immuni.2007.01.015. Immunity. 2007. PMID: 17368054
Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).
Newell EW, Ely LK, Kruse AC, Reay PA, Rodriguez SN, Lin AE, Kuhns MS, Garcia KC, Davis MM. Newell EW, et al. Among authors: kuhns ms. J Immunol. 2011 May 15;186(10):5823-32. doi: 10.4049/jimmunol.1100197. Epub 2011 Apr 13. J Immunol. 2011. PMID: 21490152 Free PMC article.
The safety on the TCR trigger.
Kuhns MS, Davis MM. Kuhns MS, et al. Cell. 2008 Nov 14;135(4):594-6. doi: 10.1016/j.cell.2008.10.033. Cell. 2008. PMID: 19013269 Free PMC article.
γδ T cells recognize a microbial encoded B cell antigen to initiate a rapid antigen-specific interleukin-17 response.
Zeng X, Wei YL, Huang J, Newell EW, Yu H, Kidd BA, Kuhns MS, Waters RW, Davis MM, Weaver CT, Chien YH. Zeng X, et al. Among authors: kuhns ms. Immunity. 2012 Sep 21;37(3):524-34. doi: 10.1016/j.immuni.2012.06.011. Epub 2012 Sep 6. Immunity. 2012. PMID: 22960222 Free PMC article.
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