Kular GS - Search Results

1

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

Komander D, Kular GS, Bain J, Elliott M, Alessi DR, Van Aalten DM. Komander D, et al. Among authors: kular gs. Biochem J. 2003 Oct 15;375(Pt 2):255-62. doi: 10.1042/BJ20031119. Biochem J. 2003. PMID: 12892559 Free PMC article.

2

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils.

Kular G, Loubtchenkov M, Swigart P, Whatmore J, Ball A, Cockcroft S, Wetzker R. Kular G, et al. Biochem J. 1997 Jul 15;325 ( Pt 2)(Pt 2):299-301. doi: 10.1042/bj3250299. Biochem J. 1997. PMID: 9230105 Free PMC article.

3

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities.

Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR. Dowler S, et al. Biochem J. 2000 Oct 1;351(Pt 1):19-31. doi: 10.1042/0264-6021:3510019. Biochem J. 2000. PMID: 11001876 Free PMC article.

4

TAK1-binding protein 1 is a pseudophosphatase.

Conner SH, Kular G, Peggie M, Shepherd S, Schüttelkopf AW, Cohen P, Van Aalten DM. Conner SH, et al. Biochem J. 2006 Nov 1;399(3):427-34. doi: 10.1042/BJ20061077. Biochem J. 2006. PMID: 16879102 Free PMC article.

5

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

Komander D, Kular G, Deak M, Alessi DR, van Aalten DM. Komander D, et al. J Biol Chem. 2005 May 13;280(19):18797-802. doi: 10.1074/jbc.M500977200. Epub 2005 Mar 1. J Biol Chem. 2005. PMID: 15741170

6

Subcellular localization of phosphatidylinositol 4,5-bisphosphate using the pleckstrin homology domain of phospholipase C delta1.

Watt SA, Kular G, Fleming IN, Downes CP, Lucocq JM. Watt SA, et al. Biochem J. 2002 May 1;363(Pt 3):657-66. doi: 10.1042/0264-6021:3630657. Biochem J. 2002. PMID: 11964166 Free PMC article.

7

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

Powell DJ, Hajduch E, Kular G, Hundal HS. Powell DJ, et al. Mol Cell Biol. 2003 Nov;23(21):7794-808. doi: 10.1128/MCB.23.21.7794-7808.2003. Mol Cell Biol. 2003. PMID: 14560023 Free PMC article.

8

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in vitro.

Kular GS, Chaudhary A, Prestwich G, Swigart P, Wetzker R, Cockcroft S. Kular GS, et al. Adv Enzyme Regul. 2002;42:53-61. doi: 10.1016/s0065-2571(01)00023-1. Adv Enzyme Regul. 2002. PMID: 12123706 No abstract available.

9

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake.

Green CJ, Göransson O, Kular GS, Leslie NR, Gray A, Alessi DR, Sakamoto K, Hundal HS. Green CJ, et al. Among authors: kular gs. J Biol Chem. 2008 Oct 10;283(41):27653-27667. doi: 10.1074/jbc.M802623200. Epub 2008 Jul 31. J Biol Chem. 2008. PMID: 18669636 Free article.

10

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

Komander D, Fairservice A, Deak M, Kular GS, Prescott AR, Peter Downes C, Safrany ST, Alessi DR, van Aalten DM. Komander D, et al. Among authors: kular gs. EMBO J. 2004 Oct 13;23(20):3918-28. doi: 10.1038/sj.emboj.7600379. Epub 2004 Sep 30. EMBO J. 2004. PMID: 15457207 Free PMC article.

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