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Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Rupanagudi KV, Kulkarni OP, Lichtnekert J, Darisipudi MN, Mulay SR, Schott B, Gruner S, Haap W, Hartmann G, Anders HJ. Rupanagudi KV, et al. Among authors: kulkarni op. Ann Rheum Dis. 2015 Feb;74(2):452-63. doi: 10.1136/annrheumdis-2013-203717. Epub 2013 Dec 3. Ann Rheum Dis. 2015. PMID: 24300027
Podocyte loss involves MDM2-driven mitotic catastrophe.
Mulay SR, Thomasova D, Ryu M, Kulkarni OP, Migliorini A, Bruns H, Gröbmayr R, Lazzeri E, Lasagni L, Liapis H, Romagnani P, Anders HJ. Mulay SR, et al. Among authors: kulkarni op. J Pathol. 2013 Jul;230(3):322-35. doi: 10.1002/path.4193. J Pathol. 2013. PMID: 23749457
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