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Mechanisms of UV-induced signal transduction.
Kulms D, Schwarz T. Kulms D, et al. J Dermatol. 2002 Apr;29(4):189-96. doi: 10.1111/j.1346-8138.2002.tb00248.x. J Dermatol. 2002. PMID: 12027082 Review.
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
Lasithiotakis KG, Sinnberg TW, Schittek B, Flaherty KT, Kulms D, Maczey E, Garbe C, Meier FE. Lasithiotakis KG, et al. Among authors: kulms d. J Invest Dermatol. 2008 Aug;128(8):2013-23. doi: 10.1038/jid.2008.44. Epub 2008 Mar 6. J Invest Dermatol. 2008. PMID: 18323781
Inhibition of PI3K-AKT-mTOR signaling sensitizes melanoma cells to cisplatin and temozolomide.
Sinnberg T, Lasithiotakis K, Niessner H, Schittek B, Flaherty KT, Kulms D, Maczey E, Campos M, Gogel J, Garbe C, Meier F. Sinnberg T, et al. Among authors: kulms d. J Invest Dermatol. 2009 Jun;129(6):1500-15. doi: 10.1038/jid.2008.379. Epub 2008 Dec 11. J Invest Dermatol. 2009. PMID: 19078992
Analysing the role of UVB-induced translational inhibition and PP2Ac deactivation in NF-κB signalling using a minimal mathematical model.
Witt J, Konrath F, Sawodny O, Ederer M, Kulms D, Sauter T. Witt J, et al. Among authors: kulms d. PLoS One. 2012;7(7):e40274. doi: 10.1371/journal.pone.0040274. Epub 2012 Jul 18. PLoS One. 2012. PMID: 22815735 Free PMC article.
Identification of new IκBα complexes by an iterative experimental and mathematical modeling approach.
Konrath F, Witt J, Sauter T, Kulms D. Konrath F, et al. Among authors: kulms d. PLoS Comput Biol. 2014 Mar 27;10(3):e1003528. doi: 10.1371/journal.pcbi.1003528. eCollection 2014 Mar. PLoS Comput Biol. 2014. PMID: 24675998 Free PMC article.
NF-kappaB and cytokines.
Kulms D, Schwarz T. Kulms D, et al. Vitam Horm. 2006;74:283-300. doi: 10.1016/S0083-6729(06)74011-0. Vitam Horm. 2006. PMID: 17027519 Review.
Anti-apoptotic NF-κB and "gain of function" mutp53 in concert act pro-apoptotic in response to UVB+IL-1 via enhanced TNF production.
Müller I, Beissert S, Kulms D. Müller I, et al. Among authors: kulms d. J Invest Dermatol. 2015 Mar;135(3):851-860. doi: 10.1038/jid.2014.481. Epub 2014 Nov 7. J Invest Dermatol. 2015. PMID: 25380350 Free PMC article.
The role of AKT/mTOR pathway in stress response to UV-irradiation: implication in skin carcinogenesis by regulation of apoptosis, autophagy and senescence.
Strozyk E, Kulms D. Strozyk E, et al. Among authors: kulms d. Int J Mol Sci. 2013 Jul 24;14(8):15260-85. doi: 10.3390/ijms140815260. Int J Mol Sci. 2013. PMID: 23887651 Free PMC article. Review.
The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.
Niessner H, Beck D, Sinnberg T, Lasithiotakis K, Maczey E, Gogel J, Venturelli S, Berger A, Mauthe M, Toulany M, Flaherty K, Schaller M, Schadendorf D, Proikas-Cezanne T, Schittek B, Garbe C, Kulms D, Meier F. Niessner H, et al. Among authors: kulms d. J Invest Dermatol. 2011 Feb;131(2):468-79. doi: 10.1038/jid.2010.297. Epub 2010 Oct 14. J Invest Dermatol. 2011. PMID: 20944654
NF{kappa}B-dependent down-regulation of tumor necrosis factor receptor-associated proteins contributes to interleukin-1-mediated enhancement of ultraviolet B-induced apoptosis.
Pöppelmann B, Klimmek K, Strozyk E, Voss R, Schwarz T, Kulms D. Pöppelmann B, et al. Among authors: kulms d. J Biol Chem. 2005 Apr 22;280(16):15635-43. doi: 10.1074/jbc.M413006200. Epub 2005 Feb 21. J Biol Chem. 2005. PMID: 15723831
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