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A DNA vaccine encoding the 42 kDa C-terminus of merozoite surface protein 1 of Plasmodium falciparum induces antibody, interferon-gamma and cytotoxic T cell responses in rhesus monkeys: immuno-stimulatory effects of granulocyte macrophage-colony stimulating factor.
Kumar S, Villinger F, Oakley M, Aguiar JC, Jones TR, Hedstrom RC, Gowda K, Chute J, Stowers A, Kaslow DC, Thomas EK, Tine J, Klinman D, Hoffman SL, Weiss WW. Kumar S, et al. Immunol Lett. 2002 Apr 1;81(1):13-24. doi: 10.1016/s0165-2478(01)00316-9. Immunol Lett. 2002. PMID: 11841841
Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes.
Epstein JE, Gorak EJ, Charoenvit Y, Wang R, Freydberg N, Osinowo O, Richie TL, Stoltz EL, Trespalacios F, Nerges J, Ng J, Fallarme-Majam V, Abot E, Goh L, Parker S, Kumar S, Hedstrom RC, Norman J, Stout R, Hoffman SL. Epstein JE, et al. Among authors: kumar s. Hum Gene Ther. 2002 Sep 1;13(13):1551-60. doi: 10.1089/10430340260201644. Hum Gene Ther. 2002. PMID: 12228010
PfSPATR, a Plasmodium falciparum protein containing an altered thrombospondin type I repeat domain is expressed at several stages of the parasite life cycle and is the target of inhibitory antibodies.
Chattopadhyay R, Rathore D, Fujioka H, Kumar S, de la Vega P, Haynes D, Moch K, Fryauff D, Wang R, Carucci DJ, Hoffman SL. Chattopadhyay R, et al. Among authors: kumar s. J Biol Chem. 2003 Jul 11;278(28):25977-81. doi: 10.1074/jbc.M300865200. Epub 2003 Apr 25. J Biol Chem. 2003. PMID: 12716913 Free article.
Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA.
Richie TL, Charoenvit Y, Wang R, Epstein JE, Hedstrom RC, Kumar S, Luke TC, Freilich DA, Aguiar JC, Sacci JB Jr, Sedegah M, Nosek RA Jr, De La Vega P, Berzins MP, Majam VF, Abot EN, Ganeshan H, Richie NO, Banania JG, Baraceros MF, Geter TG, Mere R, Bebris L, Limbach K, Hickey BW, Lanar DE, Ng J, Shi M, Hobart PM, Norman JA, Soisson LA, Hollingdale MR, Rogers WO, Doolan DL, Hoffman SL. Richie TL, et al. Among authors: kumar s. Hum Vaccin Immunother. 2012 Nov 1;8(11):1564-84. doi: 10.4161/hv.22129. Epub 2012 Nov 1. Hum Vaccin Immunother. 2012. PMID: 23151451 Free PMC article. Clinical Trial.
Plasmodium falciparum. Mechanisms of innate and acquired protection against Plasmodium falciparum in Javanese transmigrant adults and children newly resident in malaria-endemic Northwest Papua.
Keenihan SH, Gramzinksi R, Ratiwayanto S, Hadiputranto H, Riberu W, Soebianto S, Rusjdy F, Syafruddin D, Kartikasari A, Djojosubroto M, Setianingsih I, Harahap A, Krisin, Fryauff D, Richie T, Charoenvit Y, Marwoto HA, Kumar S, Hoffman S, Marzuki S, Baird K. Keenihan SH, et al. Among authors: kumar s. Adv Exp Med Biol. 2003;531:83-102. Adv Exp Med Biol. 2003. PMID: 12916783 No abstract available.
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