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20,847 results
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Allosteric mechanisms in P450eryF probed with 1-pyrenebutanol, a novel fluorescent substrate.
Davydov DR, Kumar S, Halpert JR. Davydov DR, et al. Among authors: kumar s. Biochem Biophys Res Commun. 2002 Jun 21;294(4):806-12. doi: 10.1016/S0006-291X(02)00565-X. Biochem Biophys Res Commun. 2002. PMID: 12061778
Identification of a novel laser dye substrate of mammalian cytochromes P450: application in rapid kinetic analysis, inhibitor screening, and directed evolution.
Kumar S. Kumar S. J Biomol Screen. 2007 Aug;12(5):677-82. doi: 10.1177/1087057107301496. Epub 2007 May 3. J Biomol Screen. 2007. PMID: 17478480
Structural and thermodynamic consequences of 1-(4-chlorophenyl)imidazole binding to cytochrome P450 2B4.
Zhao Y, Sun L, Muralidhara BK, Kumar S, White MA, Stout CD, Halpert JR. Zhao Y, et al. Among authors: kumar s. Biochemistry. 2007 Oct 16;46(41):11559-67. doi: 10.1021/bi7011614. Epub 2007 Sep 22. Biochemistry. 2007. PMID: 17887776 Free PMC article.
Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.
Kumar S, Zhao Y, Sun L, Negi SS, Halpert JR, Muralidhara BK. Kumar S, et al. Mol Pharmacol. 2007 Nov;72(5):1191-9. doi: 10.1124/mol.107.039693. Epub 2007 Aug 22. Mol Pharmacol. 2007. PMID: 17715394
Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme.
Hernandez CE, Kumar S, Liu H, Halpert JR. Hernandez CE, et al. Among authors: kumar s. Arch Biochem Biophys. 2006 Nov 1;455(1):61-7. doi: 10.1016/ Epub 2006 Sep 25. Arch Biochem Biophys. 2006. PMID: 17027909 Free PMC article.
Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.
Kumar S, Liu H, Halpert JR. Kumar S, et al. Drug Metab Dispos. 2006 Dec;34(12):1958-65. doi: 10.1124/dmd.106.012054. Epub 2006 Sep 20. Drug Metab Dispos. 2006. PMID: 16987939
Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts.
Kumar S, Halpert JR. Kumar S, et al. Biochem Biophys Res Commun. 2005 Dec 9;338(1):456-64. doi: 10.1016/j.bbrc.2005.08.080. Epub 2005 Aug 22. Biochem Biophys Res Commun. 2005. PMID: 16126165 Review.
Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.
Kumar S, Davydov DR, Halpert JR. Kumar S, et al. Drug Metab Dispos. 2005 Aug;33(8):1131-6. doi: 10.1124/dmd.105.004606. Epub 2005 May 3. Drug Metab Dispos. 2005. PMID: 15870379
Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.
Kumar S, Chen CS, Waxman DJ, Halpert JR. Kumar S, et al. J Biol Chem. 2005 May 20;280(20):19569-75. doi: 10.1074/jbc.M500158200. Epub 2005 Mar 17. J Biol Chem. 2005. PMID: 15774478
An electrostatically driven conformational transition is involved in the mechanisms of substrate binding and cooperativity in cytochrome P450eryF.
Davydov DR, Botchkareva AE, Kumar S, He YQ, Halpert JR. Davydov DR, et al. Among authors: kumar s. Biochemistry. 2004 Jun 1;43(21):6475-85. doi: 10.1021/bi036260l. Biochemistry. 2004. PMID: 15157081
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