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SIRT1 and insulin resistance.
Liang F, Kume S, Koya D. Liang F, et al. Nat Rev Endocrinol. 2009 Jul;5(7):367-73. doi: 10.1038/nrendo.2009.101. Epub 2009 May 19. Nat Rev Endocrinol. 2009. PMID: 19455179 Review.
Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation.
Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isono M, Isshiki K, Uzu T, Kashiwagi A, Koya D. Kume S, et al. Free Radic Biol Med. 2006 Jun 15;40(12):2175-82. doi: 10.1016/j.freeradbiomed.2006.02.014. Epub 2006 Mar 20. Free Radic Biol Med. 2006. PMID: 16785031
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation.
Kume S, Haneda M, Kanasaki K, Sugimoto T, Araki S, Isshiki K, Isono M, Uzu T, Guarente L, Kashiwagi A, Koya D. Kume S, et al. J Biol Chem. 2007 Jan 5;282(1):151-8. doi: 10.1074/jbc.M605904200. Epub 2006 Nov 10. J Biol Chem. 2007. PMID: 17098745
SIRT1, a calorie restriction mimetic, in a new therapeutic approach for type 2 diabetes mellitus and diabetic vascular complications.
Kume S, Uzu T, Kashiwagi A, Koya D. Kume S, et al. Endocr Metab Immune Disord Drug Targets. 2010 Mar;10(1):16-24. doi: 10.2174/187153010790827957. Endocr Metab Immune Disord Drug Targets. 2010. PMID: 20044906 Review.
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney.
Kume S, Uzu T, Horiike K, Chin-Kanasaki M, Isshiki K, Araki S, Sugimoto T, Haneda M, Kashiwagi A, Koya D. Kume S, et al. J Clin Invest. 2010 Apr;120(4):1043-55. doi: 10.1172/JCI41376. Epub 2010 Mar 24. J Clin Invest. 2010. PMID: 20335657 Free PMC article.
Sirtuins and renal diseases: relationship with aging and diabetic nephropathy.
Kitada M, Kume S, Takeda-Watanabe A, Kanasaki K, Koya D. Kitada M, et al. Clin Sci (Lond). 2013 Feb;124(3):153-64. doi: 10.1042/CS20120190. Clin Sci (Lond). 2013. PMID: 23075334 Free PMC article. Review.
Anti-aging molecule, Sirt1: a novel therapeutic target for diabetic nephropathy.
Kume S, Kitada M, Kanasaki K, Maegawa H, Koya D. Kume S, et al. Arch Pharm Res. 2013 Feb;36(2):230-6. doi: 10.1007/s12272-013-0019-4. Epub 2013 Jan 30. Arch Pharm Res. 2013. PMID: 23361587 Review.
Sirtuins as possible drug targets in type 2 diabetes.
Kitada M, Kume S, Kanasaki K, Takeda-Watanabe A, Koya D. Kitada M, et al. Curr Drug Targets. 2013 Jun 1;14(6):622-36. doi: 10.2174/1389450111314060002. Curr Drug Targets. 2013. PMID: 23445543 Review.
Ezetimibe prevents hepatic steatosis induced by a high-fat but not a high-fructose diet.
Ushio M, Nishio Y, Sekine O, Nagai Y, Maeno Y, Ugi S, Yoshizaki T, Morino K, Kume S, Kashiwagi A, Maegawa H. Ushio M, et al. Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E293-304. doi: 10.1152/ajpendo.00442.2012. Epub 2013 May 28. Am J Physiol Endocrinol Metab. 2013. PMID: 23715726
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