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Curcumin as "Curecumin": from kitchen to clinic.
Goel A, Kunnumakkara AB, Aggarwal BB. Goel A, et al. Among authors: kunnumakkara ab. Biochem Pharmacol. 2008 Feb 15;75(4):787-809. doi: 10.1016/j.bcp.2007.08.016. Epub 2007 Aug 19. Biochem Pharmacol. 2008. PMID: 17900536 Review.
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Kunnumakkara AB, et al. Cancer Res. 2007 Apr 15;67(8):3853-61. doi: 10.1158/0008-5472.CAN-06-4257. Cancer Res. 2007. PMID: 17440100
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.
Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK. Lin YG, et al. Among authors: kunnumakkara ab. Clin Cancer Res. 2007 Jun 1;13(11):3423-30. doi: 10.1158/1078-0432.CCR-06-3072. Clin Cancer Res. 2007. PMID: 17545551
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, Aggarwal BB. Sandur SK, et al. Among authors: kunnumakkara ab. Free Radic Biol Med. 2007 Aug 15;43(4):568-80. doi: 10.1016/j.freeradbiomed.2007.05.009. Epub 2007 May 16. Free Radic Biol Med. 2007. PMID: 17640567 Free PMC article.
Bioavailability of curcumin: problems and promises.
Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Anand P, et al. Among authors: kunnumakkara ab. Mol Pharm. 2007 Nov-Dec;4(6):807-18. doi: 10.1021/mp700113r. Epub 2007 Nov 14. Mol Pharm. 2007. PMID: 17999464 Review.
Curcumin and cancer: an "old-age" disease with an "age-old" solution.
Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. Anand P, et al. Among authors: kunnumakkara ab. Cancer Lett. 2008 Aug 18;267(1):133-64. doi: 10.1016/j.canlet.2008.03.025. Epub 2008 May 6. Cancer Lett. 2008. PMID: 18462866 Review.
Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Kunnumakkara AB, Anand P, Aggarwal BB. Kunnumakkara AB, et al. Cancer Lett. 2008 Oct 8;269(2):199-225. doi: 10.1016/j.canlet.2008.03.009. Epub 2008 May 13. Cancer Lett. 2008. PMID: 18479807 Review.
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IkappaBalpha kinase activation.
Sethi G, Ahn KS, Sung B, Kunnumakkara AB, Chaturvedi MM, Aggarwal BB. Sethi G, et al. Among authors: kunnumakkara ab. Biochem Pharmacol. 2008 Dec 1;76(11):1404-16. doi: 10.1016/j.bcp.2008.05.023. Epub 2008 Jul 5. Biochem Pharmacol. 2008. PMID: 18606397
Phase II trial of curcumin in patients with advanced pancreatic cancer.
Dhillon N, Aggarwal BB, Newman RA, Wolff RA, Kunnumakkara AB, Abbruzzese JL, Ng CS, Badmaev V, Kurzrock R. Dhillon N, et al. Among authors: kunnumakkara ab. Clin Cancer Res. 2008 Jul 15;14(14):4491-9. doi: 10.1158/1078-0432.CCR-08-0024. Clin Cancer Res. 2008. PMID: 18628464 Clinical Trial.
Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
Anand P, Thomas SG, Kunnumakkara AB, Sundaram C, Harikumar KB, Sung B, Tharakan ST, Misra K, Priyadarsini IK, Rajasekharan KN, Aggarwal BB. Anand P, et al. Among authors: kunnumakkara ab. Biochem Pharmacol. 2008 Dec 1;76(11):1590-611. doi: 10.1016/j.bcp.2008.08.008. Epub 2008 Aug 19. Biochem Pharmacol. 2008. PMID: 18775680 Review.
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