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Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
Kunnumakkara AB, Anand P, Aggarwal BB. Kunnumakkara AB, et al. Cancer Lett. 2008 Oct 8;269(2):199-225. doi: 10.1016/j.canlet.2008.03.009. Epub 2008 May 13. Cancer Lett. 2008. PMID: 18479807 Review.
Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway.
Mann AP, Verma A, Sethi G, Manavathi B, Wang H, Fok JY, Kunnumakkara AB, Kumar R, Aggarwal BB, Mehta K. Mann AP, et al. Among authors: kunnumakkara ab. Cancer Res. 2006 Sep 1;66(17):8788-95. doi: 10.1158/0008-5472.CAN-06-1457. Cancer Res. 2006. PMID: 16951195
Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion.
Nair AS, Shishodia S, Ahn KS, Kunnumakkara AB, Sethi G, Aggarwal BB. Nair AS, et al. Among authors: kunnumakkara ab. J Immunol. 2006 Oct 15;177(8):5612-22. doi: 10.4049/jimmunol.177.8.5612. J Immunol. 2006. PMID: 17015749
Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
Kunnumakkara AB, Nair AS, Ahn KS, Pandey MK, Yi Z, Liu M, Aggarwal BB. Kunnumakkara AB, et al. Blood. 2007 Jun 15;109(12):5112-21. doi: 10.1182/blood-2007-01-067256. Epub 2007 Mar 1. Blood. 2007. PMID: 17332240 Free PMC article.
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution.
Aggarwal BB, Sethi G, Ahn KS, Sandur SK, Pandey MK, Kunnumakkara AB, Sung B, Ichikawa H. Aggarwal BB, et al. Among authors: kunnumakkara ab. Ann N Y Acad Sci. 2006 Dec;1091:151-69. doi: 10.1196/annals.1378.063. Ann N Y Acad Sci. 2006. PMID: 17341611 Review.
Butein, a tetrahydroxychalcone, inhibits nuclear factor (NF)-kappaB and NF-kappaB-regulated gene expression through direct inhibition of IkappaBalpha kinase beta on cysteine 179 residue.
Pandey MK, Sandur SK, Sung B, Sethi G, Kunnumakkara AB, Aggarwal BB. Pandey MK, et al. Among authors: kunnumakkara ab. J Biol Chem. 2007 Jun 15;282(24):17340-50. doi: 10.1074/jbc.M700890200. Epub 2007 Apr 17. J Biol Chem. 2007. PMID: 17439942
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB. Kunnumakkara AB, et al. Cancer Res. 2007 Apr 15;67(8):3853-61. doi: 10.1158/0008-5472.CAN-06-4257. Cancer Res. 2007. PMID: 17440100
Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.
Bhutani M, Pathak AK, Nair AS, Kunnumakkara AB, Guha S, Sethi G, Aggarwal BB. Bhutani M, et al. Among authors: kunnumakkara ab. Clin Cancer Res. 2007 May 15;13(10):3024-32. doi: 10.1158/1078-0432.CCR-06-2575. Clin Cancer Res. 2007. PMID: 17505005
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway.
Lin YG, Kunnumakkara AB, Nair A, Merritt WM, Han LY, Armaiz-Pena GN, Kamat AA, Spannuth WA, Gershenson DM, Lutgendorf SK, Aggarwal BB, Sood AK. Lin YG, et al. Among authors: kunnumakkara ab. Clin Cancer Res. 2007 Jun 1;13(11):3423-30. doi: 10.1158/1078-0432.CCR-06-3072. Clin Cancer Res. 2007. PMID: 17545551
Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).
Sandur SK, Ichikawa H, Pandey MK, Kunnumakkara AB, Sung B, Sethi G, Aggarwal BB. Sandur SK, et al. Among authors: kunnumakkara ab. Free Radic Biol Med. 2007 Aug 15;43(4):568-80. doi: 10.1016/j.freeradbiomed.2007.05.009. Epub 2007 May 16. Free Radic Biol Med. 2007. PMID: 17640567 Free PMC article.
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