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Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.
Kunnumakkara AB, Nair AS, Ahn KS, Pandey MK, Yi Z, Liu M, Aggarwal BB. Kunnumakkara AB, et al. Blood. 2007 Jun 15;109(12):5112-21. doi: 10.1182/blood-2007-01-067256. Epub 2007 Mar 1. Blood. 2007. PMID: 17332240 Free PMC article.
Natural products as a gold mine for arthritis treatment.
Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB. Khanna D, et al. Among authors: kunnumakkara ab. Curr Opin Pharmacol. 2007 Jun;7(3):344-51. doi: 10.1016/j.coph.2007.03.002. Epub 2007 May 1. Curr Opin Pharmacol. 2007. PMID: 17475558 Review.
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