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The Simultaneous Inhibition of Solute Carrier Family 6 Member 19 and Breast Cancer Resistance Protein Transporters Leads to an Increase of Indoxyl Sulfate (a Uremic Toxin) in Plasma and Kidney.
Wang Q, Munteanu B, Marker A, Luo Y, Holz C, Kane JL Jr, Kuntzweiler T, Poulton EJ, Sedic M, Jayyosi Z, Riedel J, Fretland J. Wang Q, et al. Among authors: kuntzweiler t. Drug Metab Dispos. 2024 Oct 16;52(11):1288-1296. doi: 10.1124/dmd.124.001813. Drug Metab Dispos. 2024. PMID: 39251367
Amelioration of PXR-mediated CYP3A4 induction by mGluR2 modulators.
Vaz RJ, Li Y, Chellaraj V, Reiling S, Kuntzweiler T, Yang D, Shen H, Batchelor JD, Zhang Y, Chen X, McLean LR, Kosley R Jr. Vaz RJ, et al. Among authors: kuntzweiler t. Bioorg Med Chem Lett. 2018 Oct 15;28(19):3194-3196. doi: 10.1016/j.bmcl.2018.08.022. Epub 2018 Aug 20. Bioorg Med Chem Lett. 2018. PMID: 30146095
Structure-activity studies related to ABT-594, a potent nonopioid analgesic agent: effect of pyridine and azetidine ring substitutions on nicotinic acetylcholine receptor binding affinity and analgesic activity in mice.
Holladay MW, Bai H, Li Y, Lin NH, Daanen JF, Ryther KB, Wasicak JT, Kincaid JF, He Y, Hettinger AM, Huang P, Anderson DJ, Bannon AW, Buckley MJ, Campbell JE, Donnelly-Roberts DL, Gunther KL, Kim DJ, Kuntzweiler TA, Sullivan JP, Decker MW, Arneric SP. Holladay MW, et al. Among authors: kuntzweiler ta. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2797-802. doi: 10.1016/s0960-894x(98)00504-6. Bioorg Med Chem Lett. 1998. PMID: 9873625
Synthesis and structure-activity relationships of pyridine-modified analogs of 3-[2-((S)-pyrrolidinyl)methoxy]pyridine, A-84543, a potent nicotinic acetylcholine receptor agonist.
Lin NH, Gunn DE, Li Y, He Y, Bai H, Ryther KB, Kuntzweiler T, Donnelly-Roberts DL, Anderson DJ, Campbell JE, Sullivan JP, Arneric SP, Holladay MW. Lin NH, et al. Among authors: kuntzweiler t. Bioorg Med Chem Lett. 1998 Feb 3;8(3):249-54. doi: 10.1016/s0960-894x(98)00019-5. Bioorg Med Chem Lett. 1998. PMID: 9871663
ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.
Donnelly-Roberts DL, Puttfarcken PS, Kuntzweiler TA, Briggs CA, Anderson DJ, Campbell JE, Piattoni-Kaplan M, McKenna DG, Wasicak JT, Holladay MW, Williams M, Arneric SP. Donnelly-Roberts DL, et al. Among authors: kuntzweiler ta. J Pharmacol Exp Ther. 1998 May;285(2):777-86. J Pharmacol Exp Ther. 1998. PMID: 9580626
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