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Inhibitory effect of novel somatostatin peptide analogues on human cancer cell growth based on the selective inhibition of DNA polymerase β.
Kuriyama I, Miyazaki A, Tsuda Y, Yoshida H, Mizushina Y. Kuriyama I, et al. Bioorg Med Chem. 2013 Jan 15;21(2):403-11. doi: 10.1016/j.bmc.2012.11.024. Epub 2012 Nov 29. Bioorg Med Chem. 2013. PMID: 23266186
Synthesis, structure, and cytotoxicity studies of some fungal isochromanes.
Kuramochi K, Tsubaki K, Kuriyama I, Mizushina Y, Yoshida H, Takeuchi T, Kamisuki S, Sugawara F, Kobayashi S. Kuramochi K, et al. Among authors: kuriyama i. J Nat Prod. 2013 Sep 27;76(9):1737-45. doi: 10.1021/np400460m. Epub 2013 Sep 13. J Nat Prod. 2013. PMID: 24033077
Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus.
Mizushina Y, Suzuki-Fukudome H, Takeuchi T, Takemoto K, Kuriyama I, Yoshida H, Kamisuki S, Sugawara F. Mizushina Y, et al. Among authors: kuriyama i. Bioorg Med Chem. 2014 Feb 1;22(3):1070-6. doi: 10.1016/j.bmc.2013.12.038. Epub 2013 Dec 25. Bioorg Med Chem. 2014. PMID: 24411199
Inhibitory effects of catechin derivatives on mammalian DNA polymerase and topoisomerase activities and mouse one-cell zygote development.
Yoshida N, Kuriyama I, Yoshida H, Mizushina Y. Yoshida N, et al. J Biosci Bioeng. 2013 Mar;115(3):303-9. doi: 10.1016/j.jbiosc.2012.10.001. Epub 2012 Oct 31. J Biosci Bioeng. 2013. PMID: 23121921
Some catechins inhibited mammalian pols (α and β) and human topos (I and II), with (-)-epigallocatechin gallate (EGCg) the strongest inhibitor of both enzyme types, showing IC(50) values of 3.8-21.5 and 2.0-20.0 μM, respectively. ...
Some catechins inhibited mammalian pols (α and β) and human topos (I and II), with (-)-epigallocatechin gallate (EGCg) the strongest …
Pinophilins A and B, inhibitors of mammalian A-, B-, and Y-family DNA polymerases and human cancer cell proliferation.
Myobatake Y, Takeuchi T, Kuramochi K, Kuriyama I, Ishido T, Hirano K, Sugawara F, Yoshida H, Mizushina Y. Myobatake Y, et al. J Nat Prod. 2012 Feb 24;75(2):135-41. doi: 10.1021/np200523b. Epub 2012 Jan 20. J Nat Prod. 2012. PMID: 22264170
Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases.
Yamaguchi Y, Manita D, Takeuchi T, Kuramochi K, Kuriyama I, Sugawara F, Yoshida H, Mizushina Y. Yamaguchi Y, et al. Biosci Biotechnol Biochem. 2010;74(4):793-801. doi: 10.1271/bbb.90843. Epub 2010 Apr 7. Biosci Biotechnol Biochem. 2010. PMID: 20378979
Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase alpha inhibitors.
Kuramochi K, Fukudome K, Kuriyama I, Takeuchi T, Sato Y, Kamisuki S, Tsubaki K, Sugawara F, Yoshida H, Mizushina Y. Kuramochi K, et al. Bioorg Med Chem. 2009 Oct 15;17(20):7227-38. doi: 10.1016/j.bmc.2009.08.051. Epub 2009 Aug 31. Bioorg Med Chem. 2009. PMID: 19767211
Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp.
Kamisuki S, Ishimaru C, Onoda K, Kuriyama I, Ida N, Sugawara F, Yoshida H, Mizushina Y. Kamisuki S, et al. Bioorg Med Chem. 2007 May 1;15(9):3109-14. doi: 10.1016/j.bmc.2007.02.052. Epub 2007 Mar 3. Bioorg Med Chem. 2007. PMID: 17363259
New tetralols (1 and 2) are the third and second strongest inhibitors of pol lambda, but did not influence the activities of mammalian pols alpha to kappa, and showed no effect even on the activities of plant pols alpha and beta, prokaryotic pols, and other DNA metabolic enzymes …
New tetralols (1 and 2) are the third and second strongest inhibitors of pol lambda, but did not influence the activities of mammalian pols …
Structural relationship of curcumin derivatives binding to the BRCT domain of human DNA polymerase lambda.
Takeuchi T, Ishidoh T, Iijima H, Kuriyama I, Shimazaki N, Koiwai O, Kuramochi K, Kobayashi S, Sugawara F, Sakaguchi K, Yoshida H, Mizushina Y. Takeuchi T, et al. Genes Cells. 2006 Mar;11(3):223-35. doi: 10.1111/j.1365-2443.2006.00937.x. Genes Cells. 2006. PMID: 16483311
The inhibitory effect on pol lambda (full-length, i.e. intact pol lambda including the BRCA1 C- terminal [BRCT] domain) by some derivatives was stronger than that by curcumin, and monoacetylcurcumin (compound 13) was the strongest pol lambda inhibitor of all the compounds …
The inhibitory effect on pol lambda (full-length, i.e. intact pol lambda including the BRCA1 C- terminal [BRCT] domain) by some deriv …
Inhibitory effect of dipeptide alcohol derivatives containing mercapto group on eukaryotic DNA polymerase alpha.
Kato I, Kuriyama I, Asano N, Ikeda K, Yoshida H, Mizushina Y. Kato I, et al. Int J Mol Med. 2005 Oct;16(4):653-9. Int J Mol Med. 2005. PMID: 16142400
Compound 4 did not influence the activities of other replicative DNA polymerases such as delta and epsilon, and had no effect on the activities of prokaryotic DNA polymerases, nor DNA metabolic enzymes such as human immunodeficiency virus type-1 reverse transcriptase, T7 RNA poly …
Compound 4 did not influence the activities of other replicative DNA polymerases such as delta and epsilon, and had no effect on the activit …
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