Structure-based mutagenesis reveals distinct functions for Ras switch 1 and switch 2 in Sos-catalyzed guanine nucleotide exchange.
Hall BE, Yang SS, Boriack-Sjodin PA, Kuriyan J, Bar-Sagi D.
Hall BE, et al. Among authors: kuriyan j.
J Biol Chem. 2001 Jul 20;276(29):27629-37. doi: 10.1074/jbc.M101727200. Epub 2001 May 1.
J Biol Chem. 2001.
PMID: 11333268
Free article.
We have previously solved the crystal structure of nucleotide-free Ras in complex with the catalytic domain of Sos (Boriack-Sjodin, P. A., Margarit, S. M., Bar-Sagi, D., and Kuriyan, J. (1998) Nature 394, 337-343). The structure demonstrates that Sos induces conform …
We have previously solved the crystal structure of nucleotide-free Ras in complex with the catalytic domain of Sos (Boriack-Sjodin, P. A., M …