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IRS-1: auditing the effectiveness of mTOR inhibitors.
Easton JB, Kurmasheva RT, Houghton PJ. Easton JB, et al. Cancer Cell. 2006 Mar;9(3):153-5. doi: 10.1016/j.ccr.2006.02.027. Cancer Cell. 2006. PMID: 16530700 Review.
Developing new agents for the treatment of childhood cancer.
Kurmasheva R, Morton C, Houghton PJ. Kurmasheva R, et al. Curr Opin Investig Drugs. 2005 Dec;6(12):1215-27. Curr Opin Investig Drugs. 2005. PMID: 16372407 Review.
IGF-I mediated survival pathways in normal and malignant cells.
Kurmasheva RT, Houghton PJ. Kurmasheva RT, et al. Biochim Biophys Acta. 2006 Aug;1766(1):1-22. doi: 10.1016/j.bbcan.2006.05.003. Epub 2006 Jun 7. Biochim Biophys Acta. 2006. PMID: 16844299 Review.
Predicted mechanisms of resistance to mTOR inhibitors.
Kurmasheva RT, Huang S, Houghton PJ. Kurmasheva RT, et al. Br J Cancer. 2006 Oct 23;95(8):955-60. doi: 10.1038/sj.bjc.6603353. Epub 2006 Sep 5. Br J Cancer. 2006. PMID: 16953237 Free PMC article. Review.
Differential regulation of vascular endothelial growth factor by Akt and mammalian target of rapamycin inhibitors in cell lines derived from childhood solid tumors.
Kurmasheva RT, Harwood FC, Houghton PJ. Kurmasheva RT, et al. Mol Cancer Ther. 2007 May;6(5):1620-8. doi: 10.1158/1535-7163.MCT-06-0646. Epub 2007 May 4. Mol Cancer Ther. 2007. PMID: 17483438
Pediatric oncology.
Kurmasheva RT, Houghton PJ. Kurmasheva RT, et al. Curr Opin Chem Biol. 2007 Aug;11(4):424-32. doi: 10.1016/j.cbpa.2007.05.037. Epub 2007 Jul 24. Curr Opin Chem Biol. 2007. PMID: 17652007 Free PMC article. Review.
The insulin-like growth factor-1 receptor-targeting antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes with rapamycin in models of childhood sarcoma.
Kurmasheva RT, Dudkin L, Billups C, Debelenko LV, Morton CL, Houghton PJ. Kurmasheva RT, et al. Cancer Res. 2009 Oct 1;69(19):7662-71. doi: 10.1158/0008-5472.CAN-09-1693. Epub 2009 Sep 29. Cancer Res. 2009. PMID: 19789339 Free PMC article.
Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling.
Kolb EA, Gorlick R, Keir ST, Maris JM, Lock R, Carol H, Kurmasheva RT, Reynolds CP, Kang MH, Wu J, Houghton PJ, Smith MA. Kolb EA, et al. Pediatr Blood Cancer. 2012 May;58(5):815-8. doi: 10.1002/pbc.23290. Epub 2011 Aug 16. Pediatr Blood Cancer. 2012. PMID: 22052798 Free PMC article. Clinical Trial.
Initial testing (stage 1) of the phosphatidylinositol 3' kinase inhibitor, SAR245408 (XL147) by the pediatric preclinical testing program.
Reynolds CP, Kang MH, Carol H, Lock R, Gorlick R, Kolb EA, Kurmasheva RT, Keir ST, Maris JM, Billups CA, Houghton PJ, Smith MA. Reynolds CP, et al. Pediatr Blood Cancer. 2013 May;60(5):791-8. doi: 10.1002/pbc.24301. Epub 2012 Sep 21. Pediatr Blood Cancer. 2013. PMID: 23002019 Free PMC article.
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