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The parathyroid is a target organ for FGF23 in rats.
Ben-Dov IZ, Galitzer H, Lavi-Moshayoff V, Goetz R, Kuro-o M, Mohammadi M, Sirkis R, Naveh-Many T, Silver J. Ben-Dov IZ, et al. J Clin Invest. 2007 Dec;117(12):4003-8. doi: 10.1172/JCI32409. J Clin Invest. 2007. PMID: 17992255 Free PMC article.
BetaKlotho is required for metabolic activity of fibroblast growth factor 21.
Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M, Kuro-o M. Ogawa Y, et al. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7432-7. doi: 10.1073/pnas.0701600104. Epub 2007 Apr 23. Proc Natl Acad Sci U S A. 2007. PMID: 17452648 Free PMC article.
FGF23 induces left ventricular hypertrophy.
Faul C, Amaral AP, Oskouei B, Hu MC, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, Mundel P, Morales A, Scialla J, Fischer M, Soliman EZ, Chen J, Go AS, Rosas SE, Nessel L, Townsend RR, Feldman HI, St John Sutton M, Ojo A, Gadegbeku C, Di Marco GS, Reuter S, Kentrup D, Tiemann K, Brand M, Hill JA, Moe OW, Kuro-O M, Kusek JW, Keane MG, Wolf M. Faul C, et al. J Clin Invest. 2011 Nov;121(11):4393-408. doi: 10.1172/JCI46122. Epub 2011 Oct 10. J Clin Invest. 2011. PMID: 21985788 Free PMC article.
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Goetz R, Beenken A, Ibrahimi OA, Kalinina J, Olsen SK, Eliseenkova AV, Xu C, Neubert TA, Zhang F, Linhardt RJ, Yu X, White KE, Inagaki T, Kliewer SA, Yamamoto M, Kurosu H, Ogawa Y, Kuro-o M, Lanske B, Razzaque MS, Mohammadi M. Goetz R, et al. Mol Cell Biol. 2007 May;27(9):3417-28. doi: 10.1128/MCB.02249-06. Epub 2007 Mar 5. Mol Cell Biol. 2007. PMID: 17339340 Free PMC article.
288 results