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Selective cyclooxygenase-2 inhibitors show a differential ability to inhibit proliferation and induce apoptosis of colon adenocarcinoma cells.
Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Yamazaki R, et al. Among authors: kusunoki n. FEBS Lett. 2002 Nov 6;531(2):278-84. doi: 10.1016/s0014-5793(02)03535-4. FEBS Lett. 2002. PMID: 12417326
[Preventing effects of COX-2 inhibitors on rheumatoid joint destruction].
Kawai S, Kusunoki N, Kojima F. Kawai S, et al. Among authors: kusunoki n. Clin Calcium. 2003 Jun;13(6):739-45. Clin Calcium. 2003. PMID: 15775145 Japanese.
Triptolide, an active compound identified in a traditional Chinese herb, induces apoptosis of rheumatoid synovial fibroblasts.
Kusunoki N, Yamazaki R, Kitasato H, Beppu M, Aoki H, Kawai S. Kusunoki N, et al. BMC Pharmacol. 2004 Feb 17;4:2. doi: 10.1186/1471-2210-4-2. BMC Pharmacol. 2004. PMID: 15040811 Free PMC article.
Aspirin and sodium salicylate inhibit proliferation and induce apoptosis in rheumatoid synovial cells.
Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Yamazaki R, et al. Among authors: kusunoki n. J Pharm Pharmacol. 2002 Dec;54(12):1675-9. doi: 10.1211/002235702261. J Pharm Pharmacol. 2002. PMID: 12542898
Induction of apoptosis in rheumatoid synovial fibroblasts by celecoxib, but not by other selective cyclooxygenase 2 inhibitors.
Kusunoki N, Yamazaki R, Kawai S. Kusunoki N, et al. Arthritis Rheum. 2002 Dec;46(12):3159-67. doi: 10.1002/art.10692. Arthritis Rheum. 2002. PMID: 12483719
., celecoxib, etodolac, meloxicam, nimesulide, N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methanesulfonamide, and rofecoxib, under various conditions. ...
., celecoxib, etodolac, meloxicam, nimesulide, N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methanesulfonamide, and rofecoxib, under various …
Nonsteroidal anti-inflammatory drugs induce apoptosis in association with activation of peroxisome proliferator-activated receptor gamma in rheumatoid synovial cells.
Yamazaki R, Kusunoki N, Matsuzaki T, Hashimoto S, Kawai S. Yamazaki R, et al. Among authors: kusunoki n. J Pharmacol Exp Ther. 2002 Jul;302(1):18-25. doi: 10.1124/jpet.302.1.18. J Pharmacol Exp Ther. 2002. PMID: 12065695
N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methanesulfonamide (NS-398), a selective cyclooxygenase-2 inhibitor, also inhibited cell proliferation, whereas it did not cause apoptosis. ...
N-[2-(cyclohexyloxyl)-4-nitrophenyl]-methanesulfonamide (NS-398), a selective cyclooxygenase-2 inhibitor, also inhibited cell prolife
Adiponectin stimulates prostaglandin E(2) production in rheumatoid arthritis synovial fibroblasts.
Kusunoki N, Kitahara K, Kojima F, Tanaka N, Kaneko K, Endo H, Suguro T, Kawai S. Kusunoki N, et al. Arthritis Rheum. 2010 Jun;62(6):1641-9. doi: 10.1002/art.27450. Arthritis Rheum. 2010. PMID: 20222108
Pro-apoptotic effect of nonsteroidal anti-inflammatory drugs on synovial fibroblasts.
Kusunoki N, Yamazaki R, Kawai S. Kusunoki N, et al. Mod Rheumatol. 2008;18(6):542-51. doi: 10.1007/s10165-008-0102-8. Epub 2008 Jul 19. Mod Rheumatol. 2008. PMID: 18642053 Review.
A novel celecoxib derivative potently induces apoptosis of human synovial fibroblasts.
Kusunoki N, Ito T, Sakurai N, Suguro T, Handa H, Kawai S. Kusunoki N, et al. J Pharmacol Exp Ther. 2005 Aug;314(2):796-803. doi: 10.1124/jpet.105.086116. Epub 2005 May 3. J Pharmacol Exp Ther. 2005. PMID: 15870389
Here we report on the development of two novel derivatives of celecoxib, N-(2-aminoethyl)-4-[5-(4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (TT101) and 4-[5-(4-aminophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (TT201), including whethe …
Here we report on the development of two novel derivatives of celecoxib, N-(2-aminoethyl)-4-[5-(4-tolyl)-3-(trifluoromethyl)-1H-pyraz …
A celecoxib derivative potently inhibits proliferation of colon adenocarcinoma cells by induction of apoptosis.
Kusunoki N, Ito T, Sakurai N, Handa H, Kawai S. Kusunoki N, et al. Anticancer Res. 2006 Sep-Oct;26(5A):3229-36. Anticancer Res. 2006. PMID: 17094434
MATERIALS AND METHODS: The pro-apoptotic effect of N-(2-Aminoethyl)-4-[5- (4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide (TT101), a new derivative of celecoxib, was investigated on the HT-29 and SW480 colon adenocarcinoma cells. ...
MATERIALS AND METHODS: The pro-apoptotic effect of N-(2-Aminoethyl)-4-[5- (4-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfo …
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