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Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help.
Kutzler MA, Robinson TM, Chattergoon MA, Choo DK, Choo AY, Choe PY, Ramanathan MP, Parkinson R, Kudchodkar S, Tamura Y, Sidhu M, Roopchand V, Kim JJ, Pavlakis GN, Felber BK, Waldmann TA, Boyer JD, Weiner DB. Kutzler MA, et al. J Immunol. 2005 Jul 1;175(1):112-23. doi: 10.4049/jimmunol.175.1.112. J Immunol. 2005. PMID: 15972637
Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques.
Chong SY, Egan MA, Kutzler MA, Megati S, Masood A, Roopchard V, Garcia-Hand D, Montefiori DC, Quiroz J, Rosati M, Schadeck EB, Boyer JD, Pavlakis GN, Weiner DB, Sidhu M, Eldridge JH, Israel ZR. Chong SY, et al. Among authors: kutzler ma. Vaccine. 2007 Jun 21;25(26):4967-82. doi: 10.1016/j.vaccine.2006.11.070. Epub 2007 Feb 14. Vaccine. 2007. PMID: 17335943
Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.
Boyer JD, Robinson TM, Kutzler MA, Vansant G, Hokey DA, Kumar S, Parkinson R, Wu L, Sidhu MK, Pavlakis GN, Felber BK, Brown C, Silvera P, Lewis MG, Monforte J, Waldmann TA, Eldridge J, Weiner DB. Boyer JD, et al. Among authors: kutzler ma. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18648-53. doi: 10.1073/pnas.0709198104. Epub 2007 Nov 13. Proc Natl Acad Sci U S A. 2007. PMID: 18000037 Free PMC article.
113 results