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Metabolic adaptation allows Amacr-deficient mice to remain symptom-free despite low levels of mature bile acids.
Selkälä EM, Kuusisto SM, Salonurmi T, Savolainen MJ, Jauhiainen M, Pirilä PL, Kvist AP, Conzelmann E, Schmitz W, Alexson SE, Kotti TJ, Hiltunen JK, Autio KJ. Selkälä EM, et al. Among authors: kuusisto sm. Biochim Biophys Acta. 2013 Aug;1831(8):1335-43. doi: 10.1016/j.bbalip.2013.05.002. Epub 2013 May 13. Biochim Biophys Acta. 2013. PMID: 23680781
Impaired HDL2-mediated cholesterol efflux is associated with metabolic syndrome in families with early onset coronary heart disease and low HDL-cholesterol level.
Paavola T, Kuusisto S, Jauhiainen M, Kakko S, Kangas-Kontio T, Metso J, Soininen P, Ala-Korpela M, Bloigu R, Hannuksela ML, Savolainen MJ, Salonurmi T. Paavola T, et al. PLoS One. 2017 Feb 16;12(2):e0171993. doi: 10.1371/journal.pone.0171993. eCollection 2017. PLoS One. 2017. PMID: 28207870 Free PMC article.
Specific collagen XVIII isoforms promote adipose tissue accrual via mechanisms determining adipocyte number and affect fat deposition.
Aikio M, Elamaa H, Vicente D, Izzi V, Kaur I, Seppinen L, Speedy HE, Kaminska D, Kuusisto S, Sormunen R, Heljasvaara R, Jones EL, Muilu M, Jauhiainen M, Pihlajamäki J, Savolainen MJ, Shoulders CC, Pihlajaniemi T. Aikio M, et al. Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):E3043-52. doi: 10.1073/pnas.1405879111. Epub 2014 Jul 14. Proc Natl Acad Sci U S A. 2014. PMID: 25024173 Free PMC article. Clinical Trial.
Direct Estimation of HDL-Mediated Cholesterol Efflux Capacity from Serum.
Kuusisto S, Holmes MV, Ohukainen P, Kangas AJ, Karsikas M, Tiainen M, Perola M, Salomaa V, Kettunen J, Ala-Korpela M. Kuusisto S, et al. Clin Chem. 2019 Aug;65(8):1042-1050. doi: 10.1373/clinchem.2018.299222. Epub 2019 Apr 17. Clin Chem. 2019. PMID: 30996052