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CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, b cell outgrowth, and sustained neutrophilic inflammation.
Sato N, Ahuja SK, Quinones M, Kostecki V, Reddick RL, Melby PC, Kuziel WA, Ahuja SS. Sato N, et al. Among authors: kuziel wa. J Exp Med. 2000 Jul 17;192(2):205-18. doi: 10.1084/jem.192.2.205. J Exp Med. 2000. PMID: 10899907 Free PMC article.
123 results