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Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination.
Braten O, Livneh I, Ziv T, Admon A, Kehat I, Caspi LH, Gonen H, Bercovich B, Godzik A, Jahandideh S, Jaroszewski L, Sommer T, Kwon YT, Guharoy M, Tompa P, Ciechanover A. Braten O, et al. Among authors: kwon yt. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4639-47. doi: 10.1073/pnas.1608644113. Epub 2016 Jul 6. Proc Natl Acad Sci U S A. 2016. PMID: 27385826 Free PMC article.
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.
Cha-Molstad H, Yu JE, Feng Z, Lee SH, Kim JG, Yang P, Han B, Sung KW, Yoo YD, Hwang J, McGuire T, Shim SM, Song HD, Ganipisetti S, Wang N, Jang JM, Lee MJ, Kim SJ, Lee KH, Hong JT, Ciechanover A, Mook-Jung I, Kim KP, Xie XQ, Kwon YT, Kim BY. Cha-Molstad H, et al. Among authors: kwon yt. Nat Commun. 2017 Jul 24;8(1):102. doi: 10.1038/s41467-017-00085-7. Nat Commun. 2017. PMID: 28740232 Free PMC article.
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