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AIM2 sensors mediate immunity to Plasmodium infection in hepatocytes.
Marques-da-Silva C, Poudel B, Baptista RP, Peissig K, Hancox LS, Shiau JC, Pewe LL, Shears MJ, Kanneganti TD, Sinnis P, Kyle DE, Gurung P, Harty JT, Kurup SP. Marques-da-Silva C, et al. Among authors: kyle de. Proc Natl Acad Sci U S A. 2023 Jan 10;120(2):e2210181120. doi: 10.1073/pnas.2210181120. Epub 2023 Jan 3. Proc Natl Acad Sci U S A. 2023. PMID: 36595704 Free PMC article.
A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites.
Maher SP, Bakowski MA, Vantaux A, Flannery EL, Andolina C, Gupta M, Antonova-Koch Y, Argomaniz M, Cabrera-Mora M, Campo B, Chao AT, Chatterjee AK, Cheng WT, Chuenchob E, Cooper CA, Cottier K, Galinski MR, Harupa-Chung A, Ji H, Joseph SB, Lenz T, Lonardi S, Matheson J, Mikolajczak SA, Moeller T, Orban A, Padín-Irizarry V, Pan K, Péneau J, Prudhomme J, Roesch C, Ruberto AA, Sabnis SS, Saney CL, Sattabongkot J, Sereshki S, Suriyakan S, Ubalee R, Wang Y, Wasisakun P, Yin J, Popovici J, McNamara CW, Joyner CJ, Nosten F, Witkowski B, Le Roch KG, Kyle DE. Maher SP, et al. Among authors: kyle de. bioRxiv [Preprint]. 2024 Mar 25:2023.01.31.526483. doi: 10.1101/2023.01.31.526483. bioRxiv. 2024. Update in: Elife. 2025 Sep 30;13:RP98221. doi: 10.7554/eLife.98221. PMID: 36778461 Free PMC article. Updated. Preprint.
Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant Plasmodium falciparum.
Haney RS, Butler JH, Wardlaw LA, Merino EF, Mendiola V, Cooper CA, Mathew J, Tumwebaze PK, Rosenthal PJ, Cooper RA, Kyle DE, Rizopoulos Z, Baud D, Brand S, Totrov M, Carlier PR, Cassera MB. Haney RS, et al. Among authors: kyle de. ACS Infect Dis. 2025 Nov 14;11(11):3310-3322. doi: 10.1021/acsinfecdis.5c00714. Epub 2025 Oct 17. ACS Infect Dis. 2025. PMID: 41105262 Free PMC article.
First continuous in vitro culture of Plasmodium coatneyi reveals insights into barriers to human infection.
Suwanarusk R, Chua ACY, Ezenwanne CS, Snounou G, Malleret B, Kosaisavee V, Lombardini ED, Imerbsin R, Sunyakumthorn P, Katakai Y, Sakaguchi M, Kyle DE, Kawai S, Annoura T, Rénia L, Bifani P, Kaneko O, Russell B. Suwanarusk R, et al. Among authors: kyle de. Int J Parasitol. 2026 May 27:104892. doi: 10.1016/j.ijpara.2026.104892. Online ahead of print. Int J Parasitol. 2026. PMID: 42208788 Free article.
Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.
Forte B, Bellany F, Campbell PS, Chemi G, Dawson A, Anderson M, Aniweh Y, Burkhard AY, Aguiar ACC, Churchyard A, Cooper CA, Dos Santos Ferreira A, Famodimu MT, Fang FG, Hu X, Huijs T, Baud D, Jansen C, Jiménez Díaz MB, Bonnert R, Boyd S, Crespo-Fernández B, Mitasev B, Montagna S, Mok S, Murugesan D, Narwal SK, Norcross NR, Okombo J, Park H, Peet C, Pereira DB, Post JM, Reader J, Riley J, Robinson DA, Shinkyo R, Simeons FRC, Simpson L, Smith A, Smith D, Striepen J, Teles CBG, van der Laak R, Uhlemann AC, Vantaux A, Wilson C, Witkowski B, Wood G, Yeo T, Zuccotto F, Angulo-Barturen I, Baum J, Bolscher JM, Guido RVC, Birkholtz LM, Delves MJ, Dembele L, Fidock DA, Gamo FJ, Kyle DE, Maher SP, Popovici J, Walpole C, Gusovsky F, Willis PA, Read KD, Gilbert IH, Baragaña B. Forte B, et al. Among authors: kyle de. J Med Chem. 2026 Jun 11;69(11):13820-13855. doi: 10.1021/acs.jmedchem.6c00823. Epub 2026 Jun 2. J Med Chem. 2026. PMID: 42227818 Free PMC article.
236 results