Kyriakis JM - Search Results

1

Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update.

Kyriakis JM, Avruch J. Kyriakis JM, et al. Physiol Rev. 2012 Apr;92(2):689-737. doi: 10.1152/physrev.00028.2011. Physiol Rev. 2012. PMID: 22535895 Free article. Review.

2

Germinal center kinase is required for optimal Jun N-terminal kinase activation by Toll-like receptor agonists and is regulated by the ubiquitin proteasome system and agonist-induced, TRAF6-dependent stabilization.

Zhong J, Kyriakis JM. Zhong J, et al. Among authors: kyriakis jm. Mol Cell Biol. 2004 Oct;24(20):9165-75. doi: 10.1128/MCB.24.20.9165-9175.2004. Mol Cell Biol. 2004. PMID: 15456887 Free PMC article.

3

Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function.

Kong DK, Georgescu SP, Cano C, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S. Kong DK, et al. Among authors: kyriakis jm. Mol Biol Cell. 2010 Apr 15;21(8):1335-49. doi: 10.1091/mbc.e09-09-0818. Epub 2010 Feb 24. Mol Biol Cell. 2010. PMID: 20181828 Free PMC article.

4

GCK is essential to systemic inflammation and pattern recognition receptor signaling to JNK and p38.

Zhong J, Gavrilescu LC, Molnár A, Murray L, Garafalo S, Kehrl JH, Simon AR, Van Etten RA, Kyriakis JM. Zhong J, et al. Among authors: kyriakis jm. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4372-7. doi: 10.1073/pnas.0812642106. Epub 2009 Feb 25. Proc Natl Acad Sci U S A. 2009. PMID: 19246396 Free PMC article. Retracted.

5

Thinking outside the box about Ras.

Kyriakis JM. Kyriakis JM. J Biol Chem. 2009 Apr 24;284(17):10993-4. doi: 10.1074/jbc.R800085200. Epub 2008 Dec 17. J Biol Chem. 2009. PMID: 19091742 Free PMC article. Review. No abstract available.

6

Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling.

Xu D, Patten RD, Force T, Kyriakis JM. Xu D, et al. Among authors: kyriakis jm. Mol Cell Biol. 2006 Jul;26(13):5043-54. doi: 10.1128/MCB.02387-05. Mol Cell Biol. 2006. PMID: 16782890 Free PMC article.

7

Mixed-lineage kinase 3 regulates B-Raf through maintenance of the B-Raf/Raf-1 complex and inhibition by the NF2 tumor suppressor protein.

Chadee DN, Xu D, Hung G, Andalibi A, Lim DJ, Luo Z, Gutmann DH, Kyriakis JM. Chadee DN, et al. Among authors: kyriakis jm. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4463-8. doi: 10.1073/pnas.0510651103. Epub 2006 Mar 13. Proc Natl Acad Sci U S A. 2006. PMID: 16537381 Free PMC article.

8

Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function.

Xu D, Makkinje A, Kyriakis JM. Xu D, et al. Among authors: kyriakis jm. J Biol Chem. 2005 Jan 28;280(4):2924-33. doi: 10.1074/jbc.M408907200. Epub 2004 Nov 19. J Biol Chem. 2005. PMID: 15556944

9

A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation.

Chadee DN, Kyriakis JM. Chadee DN, et al. Among authors: kyriakis jm. Cell Cycle. 2004 Oct;3(10):1227-9. doi: 10.4161/cc.3.10.1187. Epub 2004 Oct 19. Cell Cycle. 2004. PMID: 15467451

10

MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation.

Chadee DN, Kyriakis JM. Chadee DN, et al. Among authors: kyriakis jm. Nat Cell Biol. 2004 Aug;6(8):770-6. doi: 10.1038/ncb1152. Epub 2004 Jul 18. Nat Cell Biol. 2004. PMID: 15258589

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