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Calcium release from the nucleus by InsP3 receptor channels.
Stehno-Bittel L, Lückhoff A, Clapham DE. Stehno-Bittel L, et al. Neuron. 1995 Jan;14(1):163-7. doi: 10.1016/0896-6273(95)90250-3. Neuron. 1995. PMID: 7530018
The nucleus is surrounded by a double membrane separating it from the cytoplasm. The perinuclear space is continuous with endoplasmic reticulum, and the nuclear outer membrane shares many features with the reticular membrane. ...The channel is weakly regulated by ATP, is m …
The nucleus is surrounded by a double membrane separating it from the cytoplasm. The perinuclear space is continuous with endoplasmic …
The TRP family of cation channels: probing and advancing the concepts on receptor-activated calcium entry.
Zitt C, Halaszovich CR, Lückhoff A. Zitt C, et al. Prog Neurobiol. 2002 Mar;66(4):243-64. doi: 10.1016/s0301-0082(02)00002-3. Prog Neurobiol. 2002. PMID: 11960680 Review.
Stimulation of membrane receptors linked to a phospholipase C and the subsequent production of the second messengers diacylglycerol and inositol-1,4,5-trisphosphate (InsP(3)) is a signaling pathway of fundamental importance in eukaryotic cells. ...A major exc …
Stimulation of membrane receptors linked to a phospholipase C and the subsequent production of the second messengers diacylglycerol a …
Nuclear ion channels and regulation of the nuclear pore.
Stehno-Bittel L, Perez-Terzic C, Luckhoff A, Clapham DE. Stehno-Bittel L, et al. Soc Gen Physiol Ser. 1996;51:195-207. Soc Gen Physiol Ser. 1996. PMID: 8809944 Review.
Multiple K+, Cl-, and nonselective cationic nuclear channels have been identified in a variety of cell types from coconut endosperm to cardiac myocytes. ...
Multiple K+, Cl-, and nonselective cationic nuclear channels have been identified in a variety of cell types from coconut endosperm t …
Calcium channels activated by depletion of internal calcium stores in A431 cells.
Lückhoff A, Clapham DE. Lückhoff A, et al. Biophys J. 1994 Jul;67(1):177-82. doi: 10.1016/S0006-3495(94)80467-9. Biophys J. 1994. PMID: 7918985 Free PMC article.
The channel had a slope conductance of 2 pS with 200 mM CaCl2 and 16 pS with 160 mM BaCl2 in the pipette. Channel activity quickly ran down in excised inside-out patches and was not restored by InsP3 and/or InsP4. ...
The channel had a slope conductance of 2 pS with 200 mM CaCl2 and 16 pS with 160 mM BaCl2 in the pipette. Channel activity quickly ra …
Inositol 1,3,4,5-tetrakisphosphate activates an endothelial Ca(2+)-permeable channel.
Lückhoff A, Clapham DE. Lückhoff A, et al. Nature. 1992 Jan 23;355(6358):356-8. doi: 10.1038/355356a0. Nature. 1992. PMID: 1309941
Here we characterize a novel inositol 1,3,4,5-tetrakisphosphate (InsP4) and Ca(2+)-sensitive Ca(2+)-permeable channel in endothelial cells. ...Our results suggest a molecular mechanism which is likely to be important for receptor-mediated Ca2+ entry....
Here we characterize a novel inositol 1,3,4,5-tetrakisphosphate (InsP4) and Ca(2+)-sensitive Ca(2+)-permeable channel in endothelial …
Two-dimensional model of calcium waves reproduces the patterns observed in Xenopus oocytes.
Girard S, Lückhoff A, Lechleiter J, Sneyd J, Clapham D. Girard S, et al. Biophys J. 1992 Feb;61(2):509-17. doi: 10.1016/S0006-3495(92)81855-6. Biophys J. 1992. PMID: 1547335 Free PMC article.
Extending an existing ordinary differential equation (ODE) model of Ca2+ oscillations to two spatial dimensions, we develop a partial differential equation (PDE) model of Ca2+ excitability. ...
Extending an existing ordinary differential equation (ODE) model of Ca2+ oscillations to two spatial dimensions, we develop a partial …
Cloning and functional expression of a human Ca2+-permeable cation channel activated by calcium store depletion.
Zitt C, Zobel A, Obukhov AG, Harteneck C, Kalkbrenner F, Lückhoff A, Schultz G. Zitt C, et al. Neuron. 1996 Jun;16(6):1189-96. doi: 10.1016/s0896-6273(00)80145-2. Neuron. 1996. PMID: 8663995
Depletion of intracellular calcium stores generates a signal that activates Ca2+-permeable channels in the plasma membrane. We have identified a human cDNA, TRPC1A, from a human fetal brain cDNA library. ...We conclude that TRPC1A encodes a Ca2+-permea …
Depletion of intracellular calcium stores generates a signal that activates Ca2+-permeable channels in the plasma membrane. We have i …
Ca(2+)-permeable large-conductance nonselective cation channels in rat basophilic leukemia cells.
Obukhov AG, Jones SV, Degtiar VE, Lückhoff A, Schultz G, Hescheler J. Obukhov AG, et al. Am J Physiol. 1995 Nov;269(5 Pt 1):C1119-25. doi: 10.1152/ajpcell.1995.269.5.C1119. Am J Physiol. 1995. PMID: 7491899
The channels had a conductance of 250 pS in 135 mM Na+ and 70 pS in 100 mM Ca2+. The permeability (P) ratio was PCa/PNa/PCs/PMg = 16:1:0.6:0.6. ...
The channels had a conductance of 250 pS in 135 mM Na+ and 70 pS in 100 mM Ca2+. The permeability (P) ratio was PCa/PNa/PCs/PMg = 16: …
Regulation of heterologously expressed transient receptor potential-like channels by calcium ions.
Obukhov AG, Schultz G, Lückhoff A. Obukhov AG, et al. Neuroscience. 1998 Jul;85(2):487-95. doi: 10.1016/s0306-4522(97)00616-7. Neuroscience. 1998. PMID: 9622246
The Drosophila melanogaster gene product TRPL (transient receptor potential-like) is a Ca2+-permeable cation channel that contributes to the light-induced Ca2+ entry in Drosophila photoreceptors and bears homology to several recently cloned mammalian channels. ...Moreover, …
The Drosophila melanogaster gene product TRPL (transient receptor potential-like) is a Ca2+-permeable cation channel that contributes …
Effects of cinnarizine on calcium and pressure-dependent potassium currents in guinea pig vestibular hair cells.
Düwel P, Haasler T, Jüngling E, Duong TA, Westhofen M, Lückhoff A. Düwel P, et al. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):441-8. doi: 10.1007/s00210-005-1077-z. Epub 2005 Jul 23. Naunyn Schmiedebergs Arch Pharmacol. 2005. PMID: 16041595
These currents are inhibited by charybdotoxin, a blocker of Ca2+-dependent K+ channels. On the other hand, cinnarizine is a blocker of voltage-gated Ca2+ currents in hair cells and is used as a drug in conditions with vestibular vertigo. ...It reduces Ca2+ in …
These currents are inhibited by charybdotoxin, a blocker of Ca2+-dependent K+ channels. On the other hand, cinnarizine is a bl …
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