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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1923 1
1935 1
1936 1
1940 1
1941 1
1943 1
1944 1
1945 3
1946 7
1947 7
1948 5
1949 4
1950 7
1951 15
1952 18
1953 11
1954 12
1955 13
1956 9
1957 12
1958 16
1959 13
1960 31
1961 39
1962 59
1963 100
1964 204
1965 182
1966 215
1967 226
1968 266
1969 312
1970 305
1971 393
1972 369
1973 319
1974 378
1975 360
1976 308
1977 284
1978 251
1979 267
1980 253
1981 252
1982 268
1983 290
1984 300
1985 299
1986 337
1987 344
1988 387
1989 450
1990 567
1991 590
1992 645
1993 668
1994 680
1995 632
1996 705
1997 703
1998 739
1999 757
2000 782
2001 790
2002 769
2003 800
2004 920
2005 942
2006 929
2007 942
2008 934
2009 956
2010 952
2011 977
2012 1003
2013 978
2014 953
2015 953
2016 965
2017 930
2018 919
2019 897
2020 900
2021 300
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32,267 results
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Page 1
Production of L-valine from metabolically engineered Corynebacterium glutamicum.
Wang X, Zhang H, Quinn PJ. Wang X, et al. Appl Microbiol Biotechnol. 2018 May;102(10):4319-4330. doi: 10.1007/s00253-018-8952-2. Epub 2018 Mar 29. Appl Microbiol Biotechnol. 2018. PMID: 29594358 Review.
L-Valine is one of the three branched-chain amino acids (valine, leucine, and isoleucine) essential for animal health and important in metabolism; therefore, it is widely added in the products of food, medicine, and feed. ...Industrially competitive L-
L-Valine is one of the three branched-chain amino acids (valine, leucine, and isoleucine) essential for animal health a
Regulation of protein synthesis in porcine mammary epithelial cells by L-valine.
Zhang J, He W, Yi D, Zhao D, Song Z, Hou Y, Wu G. Zhang J, et al. Amino Acids. 2019 Apr;51(4):717-726. doi: 10.1007/s00726-019-02709-2. Epub 2019 Feb 23. Amino Acids. 2019. PMID: 30798466
PMECs were incubated with 0.05-, 0.10-, 0.25-, 0.5-, and 1.0-mM L-valine at 37 (o)C for 2 h. Cell viability and expressions of alpha-lactalbumin and beta-casein were measured after culture with L-valine for 3 days. ...Cell numbers and the synthesis of …
PMECs were incubated with 0.05-, 0.10-, 0.25-, 0.5-, and 1.0-mM L-valine at 37 (o)C for 2 h. Cell viability and expressions of …
Metabolic engineering of Bacillus subtilis for l-valine overproduction.
Westbrook AW, Ren X, Moo-Young M, Chou CP. Westbrook AW, et al. Biotechnol Bioeng. 2018 Nov;115(11):2778-2792. doi: 10.1002/bit.26789. Epub 2018 Sep 25. Biotechnol Bioeng. 2018. PMID: 29981237
We first manipulate the native l-valine biosynthetic pathway by relieving transcriptional and allosteric regulation, resulting in a >14-fold increase in the l-valine titer, compared to the wild-type strain. We subsequently identify and eliminate fac …
We first manipulate the native l-valine biosynthetic pathway by relieving transcriptional and allosteric regulation, resulting …
[Metabolic engineering of L-valine synthesis and secretory pathways in Corynebacterium glutamicum for higher production].
Zhang H, Li Y, Wang X. Zhang H, et al. Sheng Wu Gong Cheng Xue Bao. 2018 Oct 25;34(10):1606-1619. doi: 10.13345/j.cjb.180112. Sheng Wu Gong Cheng Xue Bao. 2018. PMID: 30394028 Free article. Chinese.
Corynebacterium glutamicum is the main industrial strain to produce L-valine by microbial fermentation. In this study, a low L-alanine producing C. glutamicum strain VWB-2 was constructed by knocking out the alanine aminotransferase encoding gene alaT in a hi …
Corynebacterium glutamicum is the main industrial strain to produce L-valine by microbial fermentation. In this study, a low …
Application of metabolic engineering for the biotechnological production of L-valine.
Oldiges M, Eikmanns BJ, Blombach B. Oldiges M, et al. Appl Microbiol Biotechnol. 2014 Jul;98(13):5859-70. doi: 10.1007/s00253-014-5782-8. Epub 2014 May 11. Appl Microbiol Biotechnol. 2014. PMID: 24816722 Review.
The branched chain amino acid L-valine is an essential nutrient for higher organisms, such as animals and humans. ...This review summarizes the state of the art in L-valine biosynthesis and its regulation in E. coli and C. glutamicum with respect to op …
The branched chain amino acid L-valine is an essential nutrient for higher organisms, such as animals and humans. ...This revi …
L-valine, an antialgal amino acid from Streptomyces jiujiangensis JXJ 0074(T).
Zhang BH, Chen W, Li HQ, Yang JY, Zha DM, Duan YQ, N Hozzein W, Xiao M, Gao R, Li WJ. Zhang BH, et al. Appl Microbiol Biotechnol. 2016 May;100(10):4627-36. doi: 10.1007/s00253-015-7150-8. Epub 2016 Jan 15. Appl Microbiol Biotechnol. 2016. PMID: 26767990
L-valine exhibited greater antialgal activities than both L-lysine and copper sulfate (CuSO4) did on Microcystis aeruginosa lawn. ...As a resultant, the extracellular MC-LR content was more than twice of the control from day 1 to 5. Exposure to L-va
L-valine exhibited greater antialgal activities than both L-lysine and copper sulfate (CuSO4) did on Microcystis aerugi
Elimination of biosynthetic pathways for l-valine and l-isoleucine in mitochondria enhances isobutanol production in engineered Saccharomyces cerevisiae.
Lee KM, Kim SK, Lee YG, Park KH, Seo JH. Lee KM, et al. Bioresour Technol. 2018 Nov;268:271-277. doi: 10.1016/j.biortech.2018.07.150. Epub 2018 Jul 31. Bioresour Technol. 2018. PMID: 30081287
However, the several pathways competing with isobutanol biosynthesis lead to production of substantial amounts of l-valine and l-isoleucine in mitochondria and isobutyrate, l-leucine, and ethanol in cytosol. To increase flux to isobutanol by removing b …
However, the several pathways competing with isobutanol biosynthesis lead to production of substantial amounts of l-valine and …
Genome shuffling and high-throughput screening of Brevibacterium flavum MDV1 for enhanced L-valine production.
Huang QG, Zeng BD, Liang L, Wu SG, Huang JZ. Huang QG, et al. World J Microbiol Biotechnol. 2018 Jul 23;34(8):121. doi: 10.1007/s11274-018-2502-z. World J Microbiol Biotechnol. 2018. PMID: 30039311
As the world market for L-valine grows rapidly, there is an increasing interest to develop an efficient L-valine-producing strain. ...Under fed-batch conditions in a 30 L automated fermentor, MDVR2-21 accumulated 70.1 g/L of L-v
As the world market for L-valine grows rapidly, there is an increasing interest to develop an efficient L-valine
Valsartan.
Ardiana F, Suciati, Indrayanto G. Ardiana F, et al. Profiles Drug Subst Excip Relat Methodol. 2015;40:431-93. doi: 10.1016/bs.podrm.2015.01.004. Epub 2015 Mar 21. Profiles Drug Subst Excip Relat Methodol. 2015. PMID: 26051690 Review.
Isolation and characterization of L-valine-degrading Candida maltosa DLPU-zpb for D-valine preparation from DL-valine.
Zhang CH, Xin WT, Chen M, Bi Y, Gao ZQ, Zhang J. Zhang CH, et al. Lett Appl Microbiol. 2015 Nov;61(5):453-9. doi: 10.1111/lam.12477. Epub 2015 Sep 21. Lett Appl Microbiol. 2015. PMID: 26250528 Free article.
To develop a practical process for D-valine preparation from DL-valine, L-valine was used as a sole source of carbon and nitrogen in basal minimal medium to isolate L-valine-degrading micro-organisms. ...The cells of this strain were used …
To develop a practical process for D-valine preparation from DL-valine, L-valine was used as a sole source of ca …
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