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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1962 1
1963 1
1964 3
1965 4
1966 2
1967 2
1968 6
1969 7
1970 5
1971 10
1972 2
1973 3
1974 7
1975 1
1976 4
1977 5
1978 6
1979 8
1980 7
1981 7
1982 11
1983 15
1984 20
1985 20
1986 33
1987 22
1988 19
1989 15
1990 23
1991 24
1992 31
1993 15
1994 31
1995 25
1996 30
1997 34
1998 35
1999 43
2000 44
2001 35
2002 30
2003 56
2004 41
2005 49
2006 49
2007 57
2008 57
2009 65
2010 64
2011 52
2012 56
2013 73
2014 73
2015 52
2016 50
2017 63
2018 66
2019 56
2020 50
2021 48
2022 45
2023 47
2024 44
2025 44
2026 31

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1,761 results

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Page 1
l-Cysteine-Glutathione Mixed Disulfide, a Novel Bioavailable Sulfhydryl-Modified Glutathione Precursor, Protects against Early Liver Injury Induced by Short-Term Hypercholesterolemia.
Martínez-Gili L, Fucho R, Caballero F, Núñez S, Jaara HS, Alarcón-Vila C, Rico N, Nagasawa HT, García-Ruiz C, Fernández-Checa JC, Torres S. Martínez-Gili L, et al. Chem Res Toxicol. 2025 Nov 17;38(11):1961-1976. doi: 10.1021/acs.chemrestox.5c00272. Epub 2025 Oct 23. Chem Res Toxicol. 2025. PMID: 41127960 Free PMC article.
In mammals, reduced glutathione (GSH) is a pivotal antioxidant that regulates cellular responses to redox imbalances caused by reactive oxygen and nitrogen species. ...Therefore, strategies aimed at boosting mGSH may offer therapeutic benefits against MASLD-associat …
In mammals, reduced glutathione (GSH) is a pivotal antioxidant that regulates cellular responses to redox imbalances caused by …
Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice.
Kader T, Porteous CM, Williams MJ, Gieseg SP, McCormick SP. Kader T, et al. Atherosclerosis. 2014 Dec;237(2):725-33. doi: 10.1016/j.atherosclerosis.2014.10.101. Epub 2014 Nov 1. Atherosclerosis. 2014. PMID: 25463112

OBJECTIVE: D-ribose-L-cysteine (ribose-cysteine) is a cysteine analogue designed to increase the synthesis of glutathione (GSH). ...RESULTS: Ribose-cysteine increased GSH concentrations in the liver and plasma (P < 0.05). GPx ac

…
OBJECTIVE: D-ribose-L-cysteine (ribose-cysteine) is a cysteine analogue designed to increase the synthesis of …
D-ribose-L-cysteine reduces oxidative stress and inflammatory cytokines to mitigate liver damage, and memory decline induced by copper sulfate in mice.
Isibor H, Ajayi AM, Ben-Azu B, Omeiza NA, Ademola AP, Umukoro S. Isibor H, et al. J Trace Elem Med Biol. 2022 Sep;73:127001. doi: 10.1016/j.jtemb.2022.127001. Epub 2022 May 18. J Trace Elem Med Biol. 2022. PMID: 35617721
Thus, this study was designed to evaluate the effect of D-Ribose-L-Cysteine (DRLC), a potent antioxidant agent, on copper sulfate (CuSO(4))-induced memory deterioration and the biochemical mechanisms underpinning its action in mice. ...RESULTS: DRLC reversed …
Thus, this study was designed to evaluate the effect of D-Ribose-L-Cysteine (DRLC), a potent antioxidant agent, on copp …
GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. Kremer DM, et al. Nat Commun. 2021 Aug 11;12(1):4860. doi: 10.1038/s41467-021-24859-2. Nat Commun. 2021. PMID: 34381026 Free PMC article.
Using pharmacological methods, we identify cysteine, glutathione, and lipid antioxidant function as metabolic vulnerabilities following GOT1 withdrawal. ...
Using pharmacological methods, we identify cysteine, glutathione, and lipid antioxidant function as metabolic vulnerabi …
N-acetyl-L-cysteine improves the performance of chronic cyclic heat-stressed finisher broilers but has no effect on tissue glutathione levels.
Pertiwi H, Majdeddin M, Degroote J, Zhang H, Michiels J. Pertiwi H, et al. Br Poult Sci. 2023 Dec;64(6):751-762. doi: 10.1080/00071668.2023.2264234. Epub 2023 Dec 18. Br Poult Sci. 2023. PMID: 37782109 Free article.
It was hypothesised that dietary N-acetyl-L-cysteine (NAC) in feed, as a source of cysteine, could improve the performance of heat-stressed finisher broilers by fostering glutathione (GSH) synthesis. GSH is the most abundant intracellular antioxidan …
It was hypothesised that dietary N-acetyl-L-cysteine (NAC) in feed, as a source of cysteine, could improve the performa …
Acetaminophen hepatotoxicity.
Black M. Black M. Gastroenterology. 1980 Feb;78(2):382-92. Gastroenterology. 1980. PMID: 6985598 Review. No abstract available.
The age-related change of glutathione antioxidant system in mice liver.
Jiang P, Sheng Y, Ji L. Jiang P, et al. Toxicol Mech Methods. 2013 Jul;23(6):396-401. doi: 10.3109/15376516.2013.769655. Epub 2013 Apr 23. Toxicol Mech Methods. 2013. PMID: 23343351
Cellular glutathione (GSH) antioxidant system is an important defensive system of the body, which is crucial in the protection against oxidative stress-induced liver injury. ...Next, the results showed that liver glutamate-cysteine ligase (GCL) …
Cellular glutathione (GSH) antioxidant system is an important defensive system of the body, which is crucial in the protection …
Cystathionine gamma-Lyase Protects Against Choline-Deficient High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease Through the Cysteine-Glutathione Axis in Mice.
Kim MJ, Park YR, Jang G, Han YK, Ishii I, Jang SY, Park KM. Kim MJ, et al. Antioxid Redox Signal. 2026 Jan;44(1-3):11-23. doi: 10.1177/15230864251377735. Epub 2026 Jan 15. Antioxid Redox Signal. 2026. PMID: 40958630 Free article.
AIM: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic liver disease, yet its pathogenesis remains incompletely understood. ...This study provides new insights into the molecular mechanisms of MASLD and supports the develop …
AIM: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic liver disease, yet its patho …
Liver intracellular L-cysteine concentration is maintained after inhibition of the trans-sulfuration pathway by propargylglycine in rats.
Triguero A, Barber T, García C, Puertes IR, Sastre J, Viña JR. Triguero A, et al. Br J Nutr. 1997 Nov;78(5):823-31. doi: 10.1079/bjn19970198. Br J Nutr. 1997. PMID: 9389904
To study the fate of L-cysteine and amino acid homeostasis in liver after the inhibition of the trans-sulfuration pathway, rats were treated with propargylglycine (PPG). ...These data suggest that when liver L-cysteine production was impa …
To study the fate of L-cysteine and amino acid homeostasis in liver after the inhibition of the trans-sulfuration pathw …
1,761 results