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Transformation of N epsilon-CBZ-L-lysine to CBZ-L-oxylysine using L-amino acid oxidase from Providencia alcalifaciens and L-2-hydroxy-isocaproate dehydrogenase from Lactobacillus confusus.
Hanson RL, Bembenek KS, Patel RN, Szarka LJ. Hanson RL, et al. Among authors: szarka lj. Appl Microbiol Biotechnol. 1992 Aug;37(5):599-603. doi: 10.1007/BF00240733. Appl Microbiol Biotechnol. 1992. PMID: 1368913
L-Amino acid oxidase (L-amino acid: O2 oxidoreductase [deaminating], EC 1.4.3.2) from Crotalus adamanteus venom had low activity with L-lysine but high activity with N epsilon-formyl-, t-butyoxycarbonyl(BOC)-, acetyl-, trifluoroacetyl-, or CBZ-L-lysine
L-Amino acid oxidase (L-amino acid: O2 oxidoreductase [deaminating], EC 1.4.3.2) from Crotalus adamanteus venom had low activi
[Cellular and intracellular transport of vitamin C. The physiologic aspects].
Szarka A, Lőrincz T. Szarka A, et al. Orv Hetil. 2013 Oct 20;154(42):1651-6. doi: 10.1556/OH.2013.29712. Orv Hetil. 2013. PMID: 24121217 Review. Hungarian.
Vitamin C requirement is satisfied by natural sources and vitamin C supplements in the ordinary human diet. The two major forms of vitamin C in the diet are L-ascorbic acid and L-dehydroascorbic acid. Both ascorbate and dehydroascorbate are absorbed along the entire …
Vitamin C requirement is satisfied by natural sources and vitamin C supplements in the ordinary human diet. The two major forms of vitamin C …
[The role of carbonyl stress in the development of diabetic complications].
Makk-Merczel K, Szarka A. Makk-Merczel K, et al. Among authors: szarka a. Orv Hetil. 2019 Oct;160(40):1567-1573. doi: 10.1556/650.2019.31519. Orv Hetil. 2019. PMID: 31565977 Review. Hungarian.
Finally, the clinical studies were terminated almost 20 years ago. The endogen dipeptide L-carnosine was also expected to mitigate the complications due to carbonyl stress. ...
Finally, the clinical studies were terminated almost 20 years ago. The endogen dipeptide L-carnosine was also expected to mitigate th …
Secretory diarrhea and hypokalemia associated with colonic pseudo-obstruction: A case study and systematic analysis of the literature.
Bazerbachi F, Haffar S, Szarka LA, Wang Z, Prokop LJ, Murad MH, Camilleri M. Bazerbachi F, et al. Among authors: szarka la. Neurogastroenterol Motil. 2017 Nov;29(11). doi: 10.1111/nmo.13120. Epub 2017 Jun 5. Neurogastroenterol Motil. 2017. PMID: 28580600 Review.
Median serum, stool, and urine potassium concentrations (mmol/L) were 2.4 (range: 1.9-3.1), 137 (100-180), and 17 (8-40), respectively. ...
Median serum, stool, and urine potassium concentrations (mmol/L) were 2.4 (range: 1.9-3.1), 137 (100-180), and 17 (8-40), respectivel …
The inter-relationship of ascorbate transport, metabolism and mitochondrial, plastidic respiration.
Szarka A, Bánhegyi G, Asard H. Szarka A, et al. Antioxid Redox Signal. 2013 Sep 20;19(9):1036-44. doi: 10.1089/ars.2012.5059. Epub 2013 Feb 13. Antioxid Redox Signal. 2013. PMID: 23259603 Free PMC article. Review.
RECENT ADVANCES: A bidirectional tight relationship was described between ascorbate biosynthesis and the mitochondrial electron transfer chain (mETC), since L-galactono-1,4-lactone dehydrogenase (GLDH), the enzyme catalyzing the ultimate step of ascorbate biosynthesis, use …
RECENT ADVANCES: A bidirectional tight relationship was described between ascorbate biosynthesis and the mitochondrial electron transfer cha …
Alpha-Adrenergic Agonists Stimulate Fluid Secretion in Lacrimal Gland Ducts.
Szarka D, Elekes G, Berczeli O, Vizvári E, Szalay L, Ding C, Tálosi L, Tóth-Molnár E. Szarka D, et al. Invest Ophthalmol Vis Sci. 2020 Dec 1;61(14):3. doi: 10.1167/iovs.61.14.3. Invest Ophthalmol Vis Sci. 2020. PMID: 33259608 Free PMC article.
Phenylephrine-induced secretion was completely blocked by alpha1D-adrenergic receptor blocker BMY-7378. The endothelial nitric oxide synthase (eNOS) inhibitor L-NAME or guanylyl cyclase inhibitor ODQ reduced but not completely abolished the phenylephrine-induced fluid secr …
Phenylephrine-induced secretion was completely blocked by alpha1D-adrenergic receptor blocker BMY-7378. The endothelial nitric oxide synthas …
Enzymatic synthesis of L-6-hydroxynorleucine.
Hanson RL, Schwinden MD, Banerjee A, Brzozowski DB, Chen BC, Patel BP, McNamee CG, Kodersha GA, Kronenthal DR, Patel RN, Szarka LJ. Hanson RL, et al. Among authors: szarka lj. Bioorg Med Chem. 1999 Oct;7(10):2247-52. doi: 10.1016/s0968-0896(99)00158-3. Bioorg Med Chem. 1999. PMID: 10579533
L-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and > 99% optical purity by reductive amination of 2-keto-6-hydroxyhexanoic acid using glutamate dehydrogenase from beef liver. In an alternate pr
L-6-Hydroxynorleucine, a key chiral intermediate used for synthesis of a vasopeptidase inhibitor, was prepared in 89% yield and >
D-Meson Azimuthal Anisotropy in Midcentral Pb-Pb Collisions at sqrt[s]_{NN}=5.02  TeV.
Acharya S, Adamová D, Adolfsson J, Aggarwal MM, Aglieri Rinella G, Agnello M, Agrawal N, Ahammed Z, Ahmad N, Ahn SU, Aiola S, Akindinov A, Alam SN, Alba JLB, Albuquerque DSD, Aleksandrov D, Alessandro B, Alfaro Molina R, Alici A, Alkin A, Alme J, Alt T, Altenkamper L, Altsybeev I, Alves Garcia Prado C, Andrei C, Andreou D, Andrews HA, Andronic A, Anguelov V, Anson C, Antičić T, Antinori F, Antonioli P, Anwar R, Aphecetche L, Appelshäuser H, Arcelli S, Arnaldi R, Arnold OW, Arsene IC, Arslandok M, Audurier B, Augustinus A, Averbeck R, Azmi MD, Badalà A, Baek YW, Bagnasco S, Bailhache R, Bala R, Baldisseri A, Ball M, Baral RC, Barbano AM, Barbera R, Barile F, Barioglio L, Barnaföldi GG, Barnby LS, Barret V, Bartalini P, Barth K, Bartsch E, Basile M, Bastid N, Basu S, Batigne G, Batyunya B, Batzing PC, Bearden IG, Beck H, Bedda C, Behera NK, Belikov I, Bellini F, Bello Martinez H, Bellwied R, Beltran LGE, Belyaev V, Bencedi G, Beole S, Bercuci A, Berdnikov Y, Berenyi D, Bertens RA, Berzano D, Betev L, Bhasin A, Bhat IR, Bhati AK, Bhattacharjee B, Bhom J, Bianchi L, Bianchi N, Bianchin C, Bielčík J, Bielčíková J, Bilandzic A, Biro G, Biswas R, Biswas S, Blair JT, Blau D, Blume C, Boca… See abstract for full author list ➔ Acharya S, et al. Among authors: szarka i. Phys Rev Lett. 2018 Mar 9;120(10):102301. doi: 10.1103/PhysRevLett.120.102301. Phys Rev Lett. 2018. PMID: 29570314 Free article.
Application of a new approach method (NAM) for inhalation risk assessment.
Ramanarayanan T, Szarka A, Flack S, Hinderliter P, Corley R, Charlton A, Pyles S, Wolf D. Ramanarayanan T, et al. Among authors: szarka a. Regul Toxicol Pharmacol. 2022 Aug;133:105216. doi: 10.1016/j.yrtph.2022.105216. Epub 2022 Jul 8. Regul Toxicol Pharmacol. 2022. PMID: 35817205 Free article.
The HECs for three different PSDs considered in this work ranged from 0.043 to 0.112 mg-CTN/L for nasal and oral breathing. These were compared with the estimated average daily exposure concentration for six representative application scenarios. ...
The HECs for three different PSDs considered in this work ranged from 0.043 to 0.112 mg-CTN/L for nasal and oral breathing. These wer …
Stereoselective epoxidation of 2,2-dimethyl-2H-1-benzopyran-6-carbonitrile.
Patel RN, Banerjee A, Davis B, Howell J, McNamee C, Brzozowaski D, North J, Kronenthal D, Szarka L. Patel RN, et al. Among authors: szarka l. Bioorg Med Chem. 1994 Jun;2(6):535-42. doi: 10.1016/0968-0896(94)80024-3. Bioorg Med Chem. 1994. PMID: 8000876
A two-stage process for the preparation of (+)-trans diol 3 was also developed using a 3 L cell-suspension (10% w/v, wet cells) of M. ramanniana SC 13840. The reaction was carried out in a 5-L Bioflo fermentor. The concentration of substrate 1 was 2 g L-1 wit …
A two-stage process for the preparation of (+)-trans diol 3 was also developed using a 3 L cell-suspension (10% w/v, wet cells) of M. …
68 results