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Page 1
Micronuclear collapse from oxidative damage.
Di Bona M, Chen Y, Agustinus AS, Mazzagatti A, Duran MA, Deyell M, Bronder D, Hickling J, Hong C, Scipioni L, Tedeschi G, Martin S, Li J, Ruzgaitė A, Riaz N, Shah P, D'Souza EK, Brodtman DZ, Sidoli S, Diplas B, Jalan M, Lee NY, Ordureau A, Izar B, Laughney AM, Powell S, Gratton E, Santaguida S, Maciejowski J, Ly P, Jeitner TM, Bakhoum SF. Di Bona M, et al. Science. 2024 Aug 30;385(6712):eadj8691. doi: 10.1126/science.adj8691. Epub 2024 Aug 30. Science. 2024. PMID: 39208110 Free PMC article.
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposing their enclosed chromatin to the cytosol. ...It also mediated micronuclear disintegrity under hypoxic conditions, linking tumor hypoxia wit …
Chromosome-containing micronuclei are a hallmark of aggressive cancers. Micronuclei frequently undergo irreversible collapse, exposin …
The expression and role of the Lem-D proteins Ankle2, Emerin, Lemd2, and TMPO in triple-negative breast cancer cell growth.
Rose M, Burgess JT, Cheong CM, Adams MN, Shahrouzi P, O'Byrne KJ, Richard DJ, Bolderson E. Rose M, et al. Front Oncol. 2024 Apr 24;14:1222698. doi: 10.3389/fonc.2024.1222698. eCollection 2024. Front Oncol. 2024. PMID: 38720803 Free PMC article.
METHODS: GENT2, TCGA, and KM plotter were utilized to investigate the expression and prognostic implications of several Lem-D proteins: Ankle2, TMPO, Emerin, and Lemd2 in publicly available breast cancer patient data. Immunoblotting and immunofluorescent analysis of …
METHODS: GENT2, TCGA, and KM plotter were utilized to investigate the expression and prognostic implications of several Lem-D proteins: Ankl …
Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.
Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H, Campsteijn C. Vietri M, et al. Nat Cell Biol. 2020 Jul;22(7):856-867. doi: 10.1038/s41556-020-0537-5. Epub 2020 Jun 29. Nat Cell Biol. 2020. PMID: 32601372
Instead, micronuclear ruptures result in catastrophic membrane collapse and are associated with chromosome fragmentation and chromothripsis, complex chromosome rearrangements thought to be a major driving force in cancer development. Here we use a combination of live micro …
Instead, micronuclear ruptures result in catastrophic membrane collapse and are associated with chromosome fragmentation and chromothripsis, …
Collective analysis of the expression and prognosis for LEM-domain proteins in prostate cancer.
He T, Zhang Y, Li X, Liu C, Zhu G, Yin X, Zhang Z, Zhao K, Wang Z, Zhao P, Wang K. He T, et al. World J Surg Oncol. 2022 Jun 2;20(1):174. doi: 10.1186/s12957-022-02640-z. World J Surg Oncol. 2022. PMID: 35650630 Free PMC article.
We then found that ANKLE1, EMD, and LEMD2 expressions were markedly correlated with immune cell infiltration levels. High ANKLE1, EMD, and LEMD2 expressions predicted a worse prognosis in PRAD based on immune cells. DNA methylation or/and copy number variations may …
We then found that ANKLE1, EMD, and LEMD2 expressions were markedly correlated with immune cell infiltration levels. High ANKLE1, EMD …
YEATS domain-containing protein GAS41 regulates nuclear shape by working in concert with BRD2 and the mediator complex in colorectal cancer.
Wang Z, Zhao N, Zhang S, Wang D, Wang S, Liu N. Wang Z, et al. Pharmacol Res. 2024 Aug;206:107283. doi: 10.1016/j.phrs.2024.107283. Epub 2024 Jul 2. Pharmacol Res. 2024. PMID: 38964523 Free article.
The maintenance of nuclear shape is essential for cellular homeostasis and disruptions in this process have been linked to various pathological conditions, including cancer, laminopathies, and aging. Despite the significance of nuclear shape, the precise molecular mechanis …
The maintenance of nuclear shape is essential for cellular homeostasis and disruptions in this process have been linked to various pathologi …
A new microscopy pipeline for studying the initial stages of nuclear and micronuclear rupture and repair.
Di Bona M, Bakhoum SF. Di Bona M, et al. Front Cell Dev Biol. 2024 Sep 18;12:1475095. doi: 10.3389/fcell.2024.1475095. eCollection 2024. Front Cell Dev Biol. 2024. PMID: 39359718 Free PMC article.
Nuclear envelope repair is a fundamental cellular response to stress, especially for cells experiencing frequent nuclear ruptures, such as cancer cells. Moreover, for chromosomally unstable cancer cells, characterized by the presence of micronuclei, the irreversible …
Nuclear envelope repair is a fundamental cellular response to stress, especially for cells experiencing frequent nuclear ruptures, such as …
BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins.
Young AM, Gunn AL, Hatch EM. Young AM, et al. Mol Biol Cell. 2020 Jul 15;31(15):1551-1560. doi: 10.1091/mbc.E20-01-0009. Epub 2020 May 27. Mol Biol Cell. 2020. PMID: 32459568 Free PMC article.
Here we show barrier-to-autointegration factor (BAF), a nuclear envelope protein that shapes chromatin and recruits membrane proteins in mitosis, also facilitates nuclear membrane repair in interphase, in part through recruitment of the nuclear membrane proteins emerin and Lem-do …
Here we show barrier-to-autointegration factor (BAF), a nuclear envelope protein that shapes chromatin and recruits membrane proteins in mit …
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stančáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D'Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N, Graff M, Grallert H, Grarup N, Gräßler J, Grewal J, Hamsten A, Harder MN, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Havulinna AS, Heliövaara M, Hillege H, Hofman A, Holmen O, Homuth G, Hottenga JJ, Hui J, Husemoen LL, Hysi PG, … See abstract for full author list ➔ Ried JS, et al. Nat Commun. 2016 Nov 23;7:13357. doi: 10.1038/ncomms13357. Nat Commun. 2016. PMID: 27876822 Free PMC article.
We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. ...
We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics …
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