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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 3
1991 12
1992 22
1993 20
1994 23
1995 30
1996 26
1997 31
1998 27
1999 28
2000 17
2001 33
2002 34
2003 34
2004 29
2005 36
2006 41
2007 40
2008 43
2009 40
2010 54
2011 40
2012 49
2013 41
2014 46
2015 41
2016 61
2017 65
2018 60
2019 62
2020 72
2021 32
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1,081 results
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Page 1
Mitochondrial transport mediates survival of retinal ganglion cells in affected LHON patients.
Yang TC, Yarmishyn AA, Yang YP, Lu PC, Chou SJ, Wang ML, Lin TC, Hwang DK, Chou YB, Chen SJ, Yu WK, Wang AG, Hsu CC, Chiou SH. Yang TC, et al. Hum Mol Genet. 2020 Jun 3;29(9):1454-1464. doi: 10.1093/hmg/ddaa063. Hum Mol Genet. 2020. PMID: 32277753
The characteristics of incomplete penetrance indicate that nuclear genetic and environmental factors also determine phenotypic expression of LHON. Therefore, further understanding of the role of mutant mitochondrial nicotinamide adenine dinucleotide dehydrogenase subunit p …
The characteristics of incomplete penetrance indicate that nuclear genetic and environmental factors also determine phenotypic expression of …
Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy.
Manickam AH, Michael MJ, Ramasamy S. Manickam AH, et al. Indian J Ophthalmol. 2017 Nov;65(11):1087-1092. doi: 10.4103/ijo.IJO_358_17. Indian J Ophthalmol. 2017. PMID: 29133631 Free PMC article. Review.
Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of the optic nerves, leading to vision loss. ...This review focuses on the role of mitochondrial genes in causing LHON and therapeutics …
Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of …
Treatment strategies for Leber hereditary optic neuropathy.
Jurkute N, Harvey J, Yu-Wai-Man P. Jurkute N, et al. Curr Opin Neurol. 2019 Feb;32(1):99-104. doi: 10.1097/WCO.0000000000000646. Curr Opin Neurol. 2019. PMID: 30516647 Review.
PURPOSE OF REVIEW: Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) disorder in the population and it carries a poor visual prognosis. In this article, we review the development of treatment strategies for LHON, the evide …
PURPOSE OF REVIEW: Leber hereditary optic neuropathy (LHON) is the most common primary mitochondrial DNA (mtDNA) disorder in the popu …
Mitochondrial genome variation in male LHON patients with the m.11778G > A mutation.
Piotrowska-Nowak A, Krawczyński MR, Kosior-Jarecka E, Ambroziak AM, Korwin M, Ołdak M, Tońska K, Bartnik E. Piotrowska-Nowak A, et al. Metab Brain Dis. 2020 Dec;35(8):1317-1327. doi: 10.1007/s11011-020-00605-3. Epub 2020 Aug 1. Metab Brain Dis. 2020. PMID: 32740724 Free PMC article.
In this study, we use next generation sequencing to investigate the role of whole mtDNA variation in male Polish patients with LHON and m.11778G > A, the most frequent LHON mutation. We present a possible association between mtDNA haplogroup K and variants in its …
In this study, we use next generation sequencing to investigate the role of whole mtDNA variation in male Polish patients with LHON a …
Increased Protein S-Glutathionylation in Leber's Hereditary Optic Neuropathy (LHON).
Zhou L, Chan JCY, Chupin S, Gueguen N, Desquiret-Dumas V, Koh SK, Li J, Gao Y, Deng L, Verma C, Beuerman RW, Chan ECY, Milea D, Reynier P. Zhou L, et al. Int J Mol Sci. 2020 Apr 24;21(8):3027. doi: 10.3390/ijms21083027. Int J Mol Sci. 2020. PMID: 32344771 Free PMC article.
Leber's hereditary optic neuropathy (LHON, MIM#535000) is the most common form of inherited optic neuropathies and mitochondrial DNA-related diseases. ...The significantly increased reactive oxygen species (ROS) production in the LHON group by Complex I was shown ex …
Leber's hereditary optic neuropathy (LHON, MIM#535000) is the most common form of inherited optic neuropathies and mitochondrial DNA- …
[Leber's Hereditary Optic Neuropathy].
Priglinger C, Klopstock T, Rudolph G, Priglinger SG. Priglinger C, et al. Klin Monbl Augenheilkd. 2019 Nov;236(11):1271-1282. doi: 10.1055/a-0972-1552. Epub 2019 Oct 22. Klin Monbl Augenheilkd. 2019. PMID: 31639883 German.
Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur at any age and also in women. LHON is caused by point mutations in the mitochondrial DNA, which lead to a defect in complex I of the m …
Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur a …
LHON and other optic nerve atrophies: the mitochondrial connection.
Howell N. Howell N. Dev Ophthalmol. 2003;37:94-108. doi: 10.1159/000072041. Dev Ophthalmol. 2003. PMID: 12876832 Review.
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON is complex, but the primary risk factor is a mutation in one of the seven mitochondrial genes that encode subunits of respiratory chain co …
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON
Current and Emerging Treatment Modalities for Leber's Hereditary Optic Neuropathy: A Review of the Literature.
Theodorou-Kanakari A, Karampitianis S, Karageorgou V, Kampourelli E, Kapasakis E, Theodossiadis P, Chatziralli I. Theodorou-Kanakari A, et al. Adv Ther. 2018 Oct;35(10):1510-1518. doi: 10.1007/s12325-018-0776-z. Epub 2018 Sep 1. Adv Ther. 2018. PMID: 30173326 Free PMC article. Review.
METHODS: A comprehensive literature review was performed at the PubMed database regarding the various treatment modalities for LHON. RESULTS: Treatment modalities for LHON include nutritional supplements, activators of mitochondrial biogenesis, brimonidine, and symp …
METHODS: A comprehensive literature review was performed at the PubMed database regarding the various treatment modalities for LHON. …
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