Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 3
1991 12
1992 22
1993 19
1994 23
1995 30
1996 26
1997 31
1998 27
1999 28
2000 16
2001 33
2002 34
2003 34
2004 29
2005 36
2006 41
2007 40
2008 43
2009 40
2010 54
2011 40
2012 49
2013 41
2014 45
2015 41
2016 61
2017 65
2018 62
2019 65
2020 73
2021 80
2022 96
2023 82
2024 88
2025 27

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

1,377 results

Results by year

Filters applied: . Clear all
Page 1
Mitochondrial optic neuropathies.
Carelli V, La Morgia C, Yu-Wai-Man P. Carelli V, et al. Handb Clin Neurol. 2023;194:23-42. doi: 10.1016/B978-0-12-821751-1.00010-5. Handb Clin Neurol. 2023. PMID: 36813316 Review.
LHON and DOA are both characterized by selective neurodegeneration of retinal ganglion cells (RGCs) triggered by mitochondrial dysfunction. ...LHON is a subacute, rapid, severe loss of central vision involving both eyes within weeks or months, with age of onset betw …
LHON and DOA are both characterized by selective neurodegeneration of retinal ganglion cells (RGCs) triggered by mitochondrial dysfun …
Leber Hereditary Optic Neuropathy.
Yu-Wai-Man P, Chinnery PF. Yu-Wai-Man P, et al. 2000 Oct 26 [updated 2021 Mar 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. 2000 Oct 26 [updated 2021 Mar 11]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2025. PMID: 20301353 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: Leber hereditary optic neuropathy (LHON) typically presents in young adults as bilateral, painless, subacute visual failure. ...Genetic counseling for LHON is complicated by the sex- and age-dependent penetrance of the primary mtDNA LHON …
CLINICAL CHARACTERISTICS: Leber hereditary optic neuropathy (LHON) typically presents in young adults as bilateral, painless, subacut …
LHON and other optic nerve atrophies: the mitochondrial connection.
Howell N. Howell N. Dev Ophthalmol. 2003;37:94-108. doi: 10.1159/000072041. Dev Ophthalmol. 2003. PMID: 12876832 Review.
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON is complex, but the primary risk factor is a mutation in one of the seven mitochondrial genes that encode subunits of respiratory chain co …
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON …
Leber Hereditary Optic Neuropathy: Review of Treatment and Management.
Hage R, Vignal-Clermont C. Hage R, et al. Front Neurol. 2021 May 26;12:651639. doi: 10.3389/fneur.2021.651639. eCollection 2021. Front Neurol. 2021. PMID: 34122299 Free PMC article. Review.
Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease that specifically targets the retinal ganglion cells by reducing their ability to produce enough energy to sustain. ...Few of them regain some vision after a period of ~1 year. Managem …
Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease that specifically targets the retinal gangli …
Leber Hereditary Optic Neuropathy (LHON).
Shemesh A, Sood G, Blair K, Margolin E. Shemesh A, et al. 2024 Mar 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. 2024 Mar 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan–. PMID: 29494105 Free Books & Documents.
Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder primarily affecting young males, causing sequential visual loss due to optic nerve degeneration. ...Although fundus examinations aid diagnosis, their absence doesn't rule out LHON. Recent adva …
Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder primarily affecting young males, causing sequential visual …
Mutation profile of neurodegenerative mitochondriopathy - LHON in Southern India.
Gowri P, Sathish P, Mahesh Kumar S, Sundaresan P. Gowri P, et al. Gene. 2022 Apr 20;819:146202. doi: 10.1016/j.gene.2022.146202. Epub 2022 Jan 30. Gene. 2022. PMID: 35104579
BACKGROUND: Leber's Hereditary Optic Neuropathy (LHON) is a rare mitochondriopathy causing retinal ganglion cell degeneration resulting in central vision loss. ...MT-ND4, MT-ND5, and MT-ND1 serve as the hotspot genes in this cohort. The presence of LHON associated m …
BACKGROUND: Leber's Hereditary Optic Neuropathy (LHON) is a rare mitochondriopathy causing retinal ganglion cell degeneration resulti …
Identification of the variants in PARL, the nuclear modifier gene, responsible for the expression of LHON patients in Thailand.
Istikharah R, Tun AW, Kaewsutthi S, Aryal P, Kunhapan B, Katanyoo W, Chuenkongkaew W, Lertrit P. Istikharah R, et al. Exp Eye Res. 2013 Nov;116:55-7. doi: 10.1016/j.exer.2013.08.007. Epub 2013 Aug 22. Exp Eye Res. 2013. PMID: 23973714 Review.
The present study explored variation in the PARL gene as one of the potential nuclear modifiers in the pathogenesis of Leber hereditary optic neuropathy (LHON). Ten exons, their franking introns and 3' UTR of the PARL gene were analysed. Seventeen SNPs detected were invest …
The present study explored variation in the PARL gene as one of the potential nuclear modifiers in the pathogenesis of Leber hereditary opti …
LHON: Mitochondrial Mutations and More.
Kirches E. Kirches E. Curr Genomics. 2011 Mar;12(1):44-54. doi: 10.2174/138920211794520150. Curr Genomics. 2011. PMID: 21886454 Free PMC article.
Leber's hereditary optic neuropathy (LHON) is a mitochondrial disorder leading to severe visual impairment or even blindness by death of retinal ganglion cells (RGCs). ...It is assumed that other genetic and environmental factors are needed in addition to the 'primary L …
Leber's hereditary optic neuropathy (LHON) is a mitochondrial disorder leading to severe visual impairment or even blindness by death …
Leber Hereditary Optic Neuropathy (LHON) in Patients with Presumed Childhood Monocular Amblyopia.
Petrovic Pajic S, Fakin A, Sustar Habjan M, Jarc-Vidmar M, Hawlina M. Petrovic Pajic S, et al. J Clin Med. 2023 Oct 22;12(20):6669. doi: 10.3390/jcm12206669. J Clin Med. 2023. PMID: 37892808 Free PMC article.
BACKGROUND: Most Leber hereditary optic neuropathy (LHON) cases are bilateral and sequential; however, there are rare unilateral examples, or those in which the delay of onset of vision loss between one and the other eye is longer. ...CONCLUSIONS: This report shows three d …
BACKGROUND: Most Leber hereditary optic neuropathy (LHON) cases are bilateral and sequential; however, there are rare unilateral exam …
[Hereditary Optic Neuropathies].
Rüther K. Rüther K. Klin Monbl Augenheilkd. 2018 Jun;235(6):747-763. doi: 10.1055/a-0583-6290. Epub 2018 Feb 28. Klin Monbl Augenheilkd. 2018. PMID: 29490390 Review. German.
For ophthalmologists, Leber's hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA) are of particular relevance. LHON and ADOA are diseases of the retinal ganglion cells and are caused by mitchochondrial dysfunction. LHON is based on …
For ophthalmologists, Leber's hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA) are of particular releva …
1,377 results