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Leber Hereditary Optic Neuropathy (LHON).
Shemesh A, Sood G, Margolin E. Shemesh A, et al. 2022 Sep 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. 2022 Sep 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29494105 Free Books & Documents.
Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder that typically presents in young males with sequential visual loss due to optic neuropathy....
Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder that typically presents in young males with sequential visu …
Leber Hereditary Optic Neuropathy.
Yu-Wai-Man P, Chinnery PF. Yu-Wai-Man P, et al. 2000 Oct 26 [updated 2021 Mar 11]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023. 2000 Oct 26 [updated 2021 Mar 11]. In: Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2023. PMID: 20301353 Free Books & Documents. Review.
A female (affected or unaffected) with a primary LHON-causing mtDNA variant transmits the variant to all of her offspring. In approximately 60% of families, a history of visual loss affecting maternal relatives is present. Genetic counseling for LHON is complicated …
A female (affected or unaffected) with a primary LHON-causing mtDNA variant transmits the variant to all of her offspring. In approxi …
LHON and other optic nerve atrophies: the mitochondrial connection.
Howell N. Howell N. Dev Ophthalmol. 2003;37:94-108. doi: 10.1159/000072041. Dev Ophthalmol. 2003. PMID: 12876832 Review.
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON is complex, but the primary risk factor is a mutation in one of the seven mitochondrial genes that encode subunits of respiratory chain co …
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON …
Treatment of Leber's hereditary optic neuropathy: An overview of recent developments.
Zuccarelli M, Vella-Szijj J, Serracino-Inglott A, Borg JJ. Zuccarelli M, et al. Eur J Ophthalmol. 2020 Nov;30(6):1220-1227. doi: 10.1177/1120672120936592. Epub 2020 Jun 19. Eur J Ophthalmol. 2020. PMID: 32552047 Review.
Leber's hereditary optic neuropathy (LHON) is a rare, maternally-inherited optic neuropathy caused by mitochondrial DNA point mutations and which can cause blindness. Currently, Raxone (idebenone) is the only available medicinal product authorised to treat LHON with …
Leber's hereditary optic neuropathy (LHON) is a rare, maternally-inherited optic neuropathy caused by mitochondrial DNA point mutatio …
Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy.
Manickam AH, Michael MJ, Ramasamy S. Manickam AH, et al. Indian J Ophthalmol. 2017 Nov;65(11):1087-1092. doi: 10.4103/ijo.IJO_358_17. Indian J Ophthalmol. 2017. PMID: 29133631 Free PMC article. Review.
Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of the optic nerves, leading to vision loss. ...This review focuses on the role of mitochondrial genes in causing LHON and therapeutics …
Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of …
Leber Hereditary Optic Neuropathy: Review of Treatment and Management.
Hage R, Vignal-Clermont C. Hage R, et al. Front Neurol. 2021 May 26;12:651639. doi: 10.3389/fneur.2021.651639. eCollection 2021. Front Neurol. 2021. PMID: 34122299 Free PMC article. Review.
Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease that specifically targets the retinal ganglion cells by reducing their ability to produce enough energy to sustain. The mutations of the mitochondrial DNA that cause LHON are si …
Leber hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disease that specifically targets the retinal gangli …
Leber hereditary optic neuropathy: new and emerging therapies.
Davila-Siliezar P, Carter M, Milea D, Lee AG. Davila-Siliezar P, et al. Curr Opin Ophthalmol. 2022 Nov 1;33(6):574-578. doi: 10.1097/ICU.0000000000000891. Epub 2022 Aug 24. Curr Opin Ophthalmol. 2022. PMID: 36066375 Review.
Since the initial approval of the drug in 2015 in Europe, recent trials have evaluated its role as prolonged treatment in LHON. Gene therapy has recently emerged as a promising alternative for the treatment of LHON. ...SUMMARY: Historically, LHON has been con …
Since the initial approval of the drug in 2015 in Europe, recent trials have evaluated its role as prolonged treatment in LHON. Gene …
Leber hereditary optic neuropathy-new insights and old challenges.
Sundaramurthy S, SelvaKumar A, Ching J, Dharani V, Sarangapani S, Yu-Wai-Man P. Sundaramurthy S, et al. Graefes Arch Clin Exp Ophthalmol. 2021 Sep;259(9):2461-2472. doi: 10.1007/s00417-020-04993-1. Epub 2020 Nov 13. Graefes Arch Clin Exp Ophthalmol. 2021. PMID: 33185731 Review.
LHON is characterized by bilateral subacute loss of vision due to the preferential loss of retinal ganglion cells (RGCs) within the inner retina, resulting in optic nerve degeneration. This review describes the clinical features associated with mtDNA LHON mutations …
LHON is characterized by bilateral subacute loss of vision due to the preferential loss of retinal ganglion cells (RGCs) within the i …
[Leber's Hereditary Optic Neuropathy].
Priglinger C, Klopstock T, Rudolph G, Priglinger SG. Priglinger C, et al. Klin Monbl Augenheilkd. 2019 Nov;236(11):1271-1282. doi: 10.1055/a-0972-1552. Epub 2019 Oct 22. Klin Monbl Augenheilkd. 2019. PMID: 31639883 German.
Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur at any age and also in women. LHON is caused by point mutations in the mitochondrial DNA, which lead to a defect in complex I of the m …
Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur a …
Mutation profile of neurodegenerative mitochondriopathy - LHON in Southern India.
Gowri P, Sathish P, Mahesh Kumar S, Sundaresan P. Gowri P, et al. Gene. 2022 Apr 20;819:146202. doi: 10.1016/j.gene.2022.146202. Epub 2022 Jan 30. Gene. 2022. PMID: 35104579
BACKGROUND: Leber's Hereditary Optic Neuropathy (LHON) is a rare mitochondriopathy causing retinal ganglion cell degeneration resulting in central vision loss. ...MT-ND4, MT-ND5, and MT-ND1 serve as the hotspot genes in this cohort. The presence of LHON associated m …
BACKGROUND: Leber's Hereditary Optic Neuropathy (LHON) is a rare mitochondriopathy causing retinal ganglion cell degeneration resulti …
1,238 results