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Table representation of search results timeline featuring number of search results per year.

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1989 1
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1996 26
1997 31
1998 27
1999 28
2000 16
2001 33
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2003 34
2004 29
2005 36
2006 41
2007 40
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2010 54
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Page 1
Leber Hereditary Optic Neuropathy.
Yu-Wai-Man P, Chinnery PF. Yu-Wai-Man P, et al. 2000 Oct 26 [updated 2021 Mar 11]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Mirzaa GM, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022. 2000 Oct 26 [updated 2021 Mar 11]. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Mirzaa GM, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2022. PMID: 20301353 Free Books & Documents. Review.
A female (affected or unaffected) with a primary LHON-causing mtDNA variant transmits the variant to all of her offspring. In approximately 60% of families, a history of visual loss affecting maternal relatives is present. Genetic counseling for LHON is complicated …
A female (affected or unaffected) with a primary LHON-causing mtDNA variant transmits the variant to all of her offspring. In approxi …
Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy.
Manickam AH, Michael MJ, Ramasamy S. Manickam AH, et al. Indian J Ophthalmol. 2017 Nov;65(11):1087-1092. doi: 10.4103/ijo.IJO_358_17. Indian J Ophthalmol. 2017. PMID: 29133631 Free PMC article. Review.
Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of the optic nerves, leading to vision loss. ...This review focuses on the role of mitochondrial genes in causing LHON and therapeutics …
Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of …
Leber Hereditary Optic Neuropathy-Light at the End of the Tunnel?
Kim US, Jurkute N, Yu-Wai-Man P. Kim US, et al. Asia Pac J Ophthalmol (Phila). 2018 Jul-Aug;7(4):242-245. doi: 10.22608/APO.2018293. Epub 2018 Jul 15. Asia Pac J Ophthalmol (Phila). 2018. PMID: 30008192 Free article. Review.
Leber hereditary optic neuropathy (LHON) is an important cause of mitochondrial blindness. The majority of patients harbor one of three mitochondrial DNA (mtDNA) point mutations, m.3460G>A, m.11778G>A, and m.14484T>C, which all affect complex I subunits of the mit …
Leber hereditary optic neuropathy (LHON) is an important cause of mitochondrial blindness. The majority of patients harbor one of thr …
LHON and other optic nerve atrophies: the mitochondrial connection.
Howell N. Howell N. Dev Ophthalmol. 2003;37:94-108. doi: 10.1159/000072041. Dev Ophthalmol. 2003. PMID: 12876832 Review.
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON is complex, but the primary risk factor is a mutation in one of the seven mitochondrial genes that encode subunits of respiratory chain co …
The clinical, biochemical and genetic features of Leber's hereditary optic neuropathy (LHON) are reviewed. The etiology of LHON …
Treatment of Leber's hereditary optic neuropathy: An overview of recent developments.
Zuccarelli M, Vella-Szijj J, Serracino-Inglott A, Borg JJ. Zuccarelli M, et al. Eur J Ophthalmol. 2020 Nov;30(6):1220-1227. doi: 10.1177/1120672120936592. Epub 2020 Jun 19. Eur J Ophthalmol. 2020. PMID: 32552047 Review.
Leber's hereditary optic neuropathy (LHON) is a rare, maternally-inherited optic neuropathy caused by mitochondrial DNA point mutations and which can cause blindness. Currently, Raxone (idebenone) is the only available medicinal product authorised to treat LHON with …
Leber's hereditary optic neuropathy (LHON) is a rare, maternally-inherited optic neuropathy caused by mitochondrial DNA point mutatio …
Leber Hereditary Optic Neuropathy (LHON).
Shemesh A, Sood G, Margolin E. Shemesh A, et al. 2021 Oct 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. 2021 Oct 22. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 29494105 Free Books & Documents.
Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder that typically presents in young males with sequential visual loss due to optic neuropathy....
Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder that typically presents in young males with sequential visu …
Exploiting hiPSCs in Leber's Hereditary Optic Neuropathy (LHON): Present Achievements and Future Perspectives.
Peron C, Maresca A, Cavaliere A, Iannielli A, Broccoli V, Carelli V, Di Meo I, Tiranti V. Peron C, et al. Front Neurol. 2021 Jun 8;12:648916. doi: 10.3389/fneur.2021.648916. eCollection 2021. Front Neurol. 2021. PMID: 34168607 Free PMC article.
LHON is characterized by selective degeneration of retinal ganglion cells (RGCs) and is the most frequent mitochondrial disease, which leads young people to blindness, in particular males. ...We here review the potentials of these new models and their impact on the future …
LHON is characterized by selective degeneration of retinal ganglion cells (RGCs) and is the most frequent mitochondrial disease, whic …
Increased Protein S-Glutathionylation in Leber's Hereditary Optic Neuropathy (LHON).
Zhou L, Chan JCY, Chupin S, Gueguen N, Desquiret-Dumas V, Koh SK, Li J, Gao Y, Deng L, Verma C, Beuerman RW, Chan ECY, Milea D, Reynier P. Zhou L, et al. Int J Mol Sci. 2020 Apr 24;21(8):3027. doi: 10.3390/ijms21083027. Int J Mol Sci. 2020. PMID: 32344771 Free PMC article.
Leber's hereditary optic neuropathy (LHON, MIM#535000) is the most common form of inherited optic neuropathies and mitochondrial DNA-related diseases. ...The significantly increased reactive oxygen species (ROS) production in the LHON group by Complex I was shown ex …
Leber's hereditary optic neuropathy (LHON, MIM#535000) is the most common form of inherited optic neuropathies and mitochondrial DNA- …
[Leber's Hereditary Optic Neuropathy].
Priglinger C, Klopstock T, Rudolph G, Priglinger SG. Priglinger C, et al. Klin Monbl Augenheilkd. 2019 Nov;236(11):1271-1282. doi: 10.1055/a-0972-1552. Epub 2019 Oct 22. Klin Monbl Augenheilkd. 2019. PMID: 31639883 German.
Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur at any age and also in women. LHON is caused by point mutations in the mitochondrial DNA, which lead to a defect in complex I of the m …
Leber's hereditary optic neuropathy (LHON) typically affects young adults with a higher prevalence in men, but can ultimately occur a …
1,148 results