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Ileocaecal resection versus infliximab for ileal Crohn's disease: retrospective 10-year follow-up of the LIR!C trial.
Oldenburg L, Haanappel AEG, Ali M, Bosman C, Buskens CJ, Ponsioen CY, D'Haens GR, Bemelman WA; LIR!C study group. Oldenburg L, et al. Lancet Gastroenterol Hepatol. 2026 Apr;11(4):314-322. doi: 10.1016/S2468-1253(25)00374-7. Epub 2026 Feb 19. Lancet Gastroenterol Hepatol. 2026. PMID: 41724174 Clinical Trial.
BACKGROUND: The LIR!C trial showed that laparoscopic ileocaecal resection is an effective alternative to infliximab therapy with similar quality-of-life outcomes in patients with uncomplicated ileocaecal Crohn's disease who …
BACKGROUND: The LIR!C trial showed that laparoscopic ileocaecal resection is an effective alternative to inflixi …
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: a randomised controlled, open-label, multicentre trial.
Ponsioen CY, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Bossuyt PMM, Hart A, Warusavitarne J, Buskens CJ, van Bodegraven AA, Brink MA, Consten ECJ, van Wagensveld BA, Rijk MCM, Crolla RMPH, Noomen CG, Houdijk APJ, Mallant RC, Boom M, Marsman WA, Stockmann HB, Mol B, de Groof AJ, Stokkers PC, D'Haens GR, Bemelman WA; LIR!C study group. Ponsioen CY, et al. Lancet Gastroenterol Hepatol. 2017 Nov;2(11):785-792. doi: 10.1016/S2468-1253(17)30248-0. Epub 2017 Aug 31. Lancet Gastroenterol Hepatol. 2017. PMID: 28838644 Clinical Trial.
BACKGROUND: Treatment of patients with ileocaecal Crohn's disease who have not responded to conventional therapy is commonly scaled up to biological agents, but surgery can also offer excellent short-term and long-term results. ...During a median follo …
BACKGROUND: Treatment of patients with ileocaecal Crohn's disease who have not responded to conventional therapy …
Cost-effectiveness of laparoscopic ileocaecal resection versus infliximab treatment of terminal ileitis in Crohn's disease: the LIR!C Trial.
de Groof EJ, Stevens TW, Eshuis EJ, Gardenbroek TJ, Bosmans JE, van Dongen JM, Mol B, Buskens CJ, Stokkers PCF, Hart A, D'Haens GR, Bemelman WA, Ponsioen CY; LIR!C study group. de Groof EJ, et al. Gut. 2019 Oct;68(10):1774-1780. doi: 10.1136/gutjnl-2018-317539. Epub 2019 Feb 1. Gut. 2019. PMID: 31233395 Clinical Trial.
OBJECTIVE: Evaluate the cost-effectiveness of laparoscopic ileocaecal resection compared with infliximab in patients with ileocaecal Crohn's disease failing conventional therapy. DESIGN: A multicentre randomised controlled trial was perfo …
OBJECTIVE: Evaluate the cost-effectiveness of laparoscopic ileocaecal resection compared with infliximab in patients with i …
Laparoscopic ileocaecal resection versus infliximab for terminal ileitis in Crohn's disease: retrospective long-term follow-up of the LIR!C trial.
Stevens TW, Haasnoot ML, D'Haens GR, Buskens CJ, de Groof EJ, Eshuis EJ, Gardenbroek TJ, Mol B, Stokkers PCF, Bemelman WA, Ponsioen CY; LIR!C study group. Stevens TW, et al. Lancet Gastroenterol Hepatol. 2020 Oct;5(10):900-907. doi: 10.1016/S2468-1253(20)30117-5. Epub 2020 Jun 30. Lancet Gastroenterol Hepatol. 2020. PMID: 32619413 Clinical Trial.
METHODS: In this retrospective follow-up study, we collected data from patients who participated in the LIR!C trial, a multicentre randomised controlled trial that compared quality of life after surgical resection versus infliximab in adult patients with non- …
METHODS: In this retrospective follow-up study, we collected data from patients who participated in the LIR!C trial, a multice …