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Year Number of Results
1962 2
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1978 3
1979 4
1980 1
1981 4
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1986 6
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1991 4
1992 7
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2000 10
2001 15
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2003 19
2004 21
2005 24
2006 22
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2008 26
2009 24
2010 37
2011 49
2012 43
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2014 50
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1,324 results

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Page 1
Endocytosis in cancer and cancer therapy.
Banushi B, Joseph SR, Lum B, Lee JJ, Simpson F. Banushi B, et al. Nat Rev Cancer. 2023 Jul;23(7):450-473. doi: 10.1038/s41568-023-00574-6. Epub 2023 May 22. Nat Rev Cancer. 2023. PMID: 37217781 Review.
Endocytosis is frequently disrupted in cancer. These disruptions lead to inappropriate retention of receptor tyrosine kinases on the tumour cell membrane, changes in the recycling of oncogenic molecules, defective signalling feedback loops and loss of cell polarity. ...Thi …
Endocytosis is frequently disrupted in cancer. These disruptions lead to inappropriate retention of receptor tyrosine kinases on the …
Hereditary Diffuse Gastric Cancer Syndrome: CDH1 Mutations and Beyond.
Hansford S, Kaurah P, Li-Chang H, Woo M, Senz J, Pinheiro H, Schrader KA, Schaeffer DF, Shumansky K, Zogopoulos G, Santos TA, Claro I, Carvalho J, Nielsen C, Padilla S, Lum A, Talhouk A, Baker-Lange K, Richardson S, Lewis I, Lindor NM, Pennell E, MacMillan A, Fernandez B, Keller G, Lynch H, Shah SP, Guilford P, Gallinger S, Corso G, Roviello F, Caldas C, Oliveira C, Pharoah PD, Huntsman DG. Hansford S, et al. JAMA Oncol. 2015 Apr;1(1):23-32. doi: 10.1001/jamaoncol.2014.168. JAMA Oncol. 2015. PMID: 26182300 Free article.
IMPORTANCE: E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting clinically defined hereditary diffuse gastric cancer (HDGC). ...MAIN OUTCOMES AND MEASURES: Accurate estimates of gastric and breast cancer risks in CDH1 mutation carrie …
IMPORTANCE: E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting clinically defined hereditary diffuse gastr …
Integrative Analysis From Multicenter Studies Identifies a WGCNA-Derived Cancer-Associated Fibroblast Signature for Ovarian Cancer.
Feng S, Xu Y, Dai Z, Yin H, Zhang K, Shen Y. Feng S, et al. Front Immunol. 2022 Jul 8;13:951582. doi: 10.3389/fimmu.2022.951582. eCollection 2022. Front Immunol. 2022. PMID: 35874760 Free PMC article.
Cancer-associated fibroblasts (CAFs) are a major contributor to tumor stromal crosstalk in the tumor microenvironment (TME) and boost tumor progression by promoting angiogenesis and lymphangiogenesis. This study aimed to identify prognostic genes associated with CAFs that …
Cancer-associated fibroblasts (CAFs) are a major contributor to tumor stromal crosstalk in the tumor microenvironment (TME) and boost …
Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies.
Li YW, Dai LJ, Wu XR, Zhao S, Xu YZ, Jin X, Xiao Y, Wang Y, Lin CJ, Zhou YF, Fu T, Yang WT, Li M, Lv H, Chen S, Grigoriadis A, Jiang YZ, Ma D, Shao ZM. Li YW, et al. Cancer Res. 2024 Nov 4;84(21):3669-3683. doi: 10.1158/0008-5472.CAN-23-4066. Cancer Res. 2024. PMID: 39186675
HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all breast cancers. Recent studies have suggested that HER2-positive breast cancer is a group of heterogeneous diseases with different sensitivities to standard treatment reg …
HER2-positive breast cancer is an aggressive subtype that accounts for 15% to 20% of all breast cancers. Recent studies have s …
Bispecific antibody based therapeutics: Strengths and challenges.
Thakur A, Huang M, Lum LG. Thakur A, et al. Blood Rev. 2018 Jul;32(4):339-347. doi: 10.1016/j.blre.2018.02.004. Epub 2018 Feb 20. Blood Rev. 2018. PMID: 29482895 Review.
New insights into the mechanisms by which tumors evade immune control have driven innovative therapeutic strategies to eliminate cancer by re-directing immune cells to tumors. Advances in protein engineering technology have generated multiple bispecific antibody (BsAb) for …
New insights into the mechanisms by which tumors evade immune control have driven innovative therapeutic strategies to eliminate cancer …
Final validation of the ProMisE molecular classifier for endometrial carcinoma in a large population-based case series.
Kommoss S, McConechy MK, Kommoss F, Leung S, Bunz A, Magrill J, Britton H, Kommoss F, Grevenkamp F, Karnezis A, Yang W, Lum A, Krämer B, Taran F, Staebler A, Lax S, Brucker SY, Huntsman DG, Gilks CB, McAlpine JN, Talhouk A. Kommoss S, et al. Ann Oncol. 2018 May 1;29(5):1180-1188. doi: 10.1093/annonc/mdy058. Ann Oncol. 2018. PMID: 29432521 Free article.
BACKGROUND: We have previously developed and confirmed a pragmatic molecular classifier for endometrial cancers; ProMisE (Proactive Molecular Risk Classifier for Endometrial Cancer). Inspired by the Cancer Genome Atlas, ProMisE identifies four prognostically …
BACKGROUND: We have previously developed and confirmed a pragmatic molecular classifier for endometrial cancers; ProMisE (Proactive M …
Integrin beta4-Targeted Cancer Immunotherapies Inhibit Tumor Growth and Decrease Metastasis.
Ruan S, Lin M, Zhu Y, Lum L, Thakur A, Jin R, Shao W, Zhang Y, Hu Y, Huang S, Hurt EM, Chang AE, Wicha MS, Li Q. Ruan S, et al. Cancer Res. 2020 Feb 15;80(4):771-783. doi: 10.1158/0008-5472.CAN-19-1145. Epub 2019 Dec 16. Cancer Res. 2020. PMID: 31843981 Free PMC article.
Integrin beta4 (ITGB4) has been shown to play an important role in the regulation of cancer stem cells (CSC). Immune targeting of ITGB4 represents a novel approach to target this cell population, with potential clinical benefit. ...Because ITGB4 is expressed by CSCs across …
Integrin beta4 (ITGB4) has been shown to play an important role in the regulation of cancer stem cells (CSC). Immune targeting of ITG …
Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer.
Zu L, He J, Zhou N, Tang Q, Liang M, Xu S. Zu L, et al. Cell Death Dis. 2023 Dec 6;14(12):798. doi: 10.1038/s41419-023-06286-x. Cell Death Dis. 2023. PMID: 38057344 Free PMC article.
Metastasis remains major cause of treatment failure in non-small cell lung cancer (NSCLC). A comprehensive characterization of the transcriptomic landscape of NSCLC-cells with organ-specific metastatic potentials would advance our understanding of NSCLC metastasis process. …
Metastasis remains major cause of treatment failure in non-small cell lung cancer (NSCLC). A comprehensive characterization of the tr …
Cancer Immunology and Immunotherapy.
Sukari A, Nagasaka M, Al-Hadidi A, Lum LG. Sukari A, et al. Anticancer Res. 2016 Nov;36(11):5593-5606. doi: 10.21873/anticanres.11144. Anticancer Res. 2016. PMID: 27793882 Review.
Hanahan and Weinberg described six distinct biological properties of cancer cells that enable tumor growth and metastasis. These properties were referred to as the traditional hallmarks of cancer. Recent discoveries further elucidated hallmarks including evasion of …
Hanahan and Weinberg described six distinct biological properties of cancer cells that enable tumor growth and metastasis. These prop …
1,324 results