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Table representation of search results timeline featuring number of search results per year.
Year | Number of Results |
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2014 | 1 |
2015 | 2 |
2018 | 1 |
2020 | 1 |
2024 | 0 |
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Page 1
Should we keep rocking? Portraits from targeting Rho kinases in cancer.
Pharmacol Res. 2020 Oct;160:105093. doi: 10.1016/j.phrs.2020.105093. Epub 2020 Jul 26.
Pharmacol Res. 2020.
PMID: 32726671
Review.
Loss of the fragile X mental retardation protein causes aberrant differentiation in human neural progenitor cells.
Sunamura N, Iwashita S, Enomoto K, Kadoshima T, Isono F.
Sunamura N, et al.
Sci Rep. 2018 Aug 2;8(1):11585. doi: 10.1038/s41598-018-30025-4.
Sci Rep. 2018.
PMID: 30072797
Free PMC article.
Interestingly, the aberrant expression of GFAP and the impaired firing was corrected by treatment with the protein kinase inhibitor LX7101. These findings underscore the modulatory roles of FMRP in human neurogenesis, and further demonstrate that the defective phenotype of …
Interestingly, the aberrant expression of GFAP and the impaired firing was corrected by treatment with the protein kinase inhibitor LX710 …
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Design, synthesis and biological characterization of selective LIMK inhibitors.
Boland S, Bourin A, Alen J, Geraets J, Schroeders P, Castermans K, Kindt N, Boumans N, Panitti L, Vanormelingen J, Fransen S, Van de Velde S, Defert O.
Boland S, et al.
Bioorg Med Chem Lett. 2015 Sep 15;25(18):4005-10. doi: 10.1016/j.bmcl.2015.07.009. Epub 2015 Jul 10.
Bioorg Med Chem Lett. 2015.
PMID: 26233434
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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.
Harrison BA, Almstead ZY, Burgoon H, Gardyan M, Goodwin NC, Healy J, Liu Y, Mabon R, Marinelli B, Samala L, Zhang Y, Stouch TR, Whitlock NA, Gopinathan S, McKnight B, Wang S, Patel N, Wilson AG, Hamman BD, Rice DS, Rawlins DB.
Harrison BA, et al.
ACS Med Chem Lett. 2014 Nov 24;6(1):84-8. doi: 10.1021/ml500367g. eCollection 2015 Jan 8.
ACS Med Chem Lett. 2014.
PMID: 25589936
Free PMC article.
The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is disclosed. ...LX7101 completed IND enabling studies and was tested in a Phase 1 clinical trial in glaucoma patients, where it showed ef …
The structure of LX7101, a dual LIM-kinase and ROCK inhibitor for the treatment of ocular hypertension and associated glaucoma, is di …
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