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Year Number of Results
1995 2
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2004 4
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46 results

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Page 1
A novel anti-pancreatic cancer agent, LY293111.
Ding XZ, Talamonti MS, Bell RH Jr, Adrian TE. Ding XZ, et al. Anticancer Drugs. 2005 Jun;16(5):467-73. doi: 10.1097/00001813-200506000-00001. Anticancer Drugs. 2005. PMID: 15846111 Review.
LY293111 may be a valuable drug for treatment of pancreatic cancer, especially in combination with gemcitabine. A double-blinded, placebo-controlled phase II clinical trial with LY293111 is currently underway. This review summarizes the current research status of …
LY293111 may be a valuable drug for treatment of pancreatic cancer, especially in combination with gemcitabine. A double-blinded, pla …
Leukotrienes Are Dispensable for Vaginal Neutrophil Recruitment as Part of the Immunopathological Response During Experimental Vulvovaginal Candidiasis.
Yano J, White DJ, Sampson AP, Wormley FL Jr, Fidel PL Jr. Yano J, et al. Front Microbiol. 2021 Nov 17;12:739385. doi: 10.3389/fmicb.2021.739385. eCollection 2021. Front Microbiol. 2021. PMID: 34867856 Free PMC article.
Based on the role leukotrienes (LTs) play in promoting inflammation, leukotriene receptor antagonists (LTRAs) targeted for LTB(4) (etalocib) or LTC(4), LTD(4,) and LTE(4) (zafirlukast or montelukast) have been shown to reduce inflammation of epithelial tissues. ...
Based on the role leukotrienes (LTs) play in promoting inflammation, leukotriene receptor antagonists (LTRAs) targeted for LTB(4) (etaloc …
Effect of a leukotriene B4 receptor antagonist, LY293111, on allergen induced responses in asthma.
Evans DJ, Barnes PJ, Spaethe SM, van Alstyne EL, Mitchell MI, O'Connor BJ. Evans DJ, et al. Thorax. 1996 Dec;51(12):1178-84. doi: 10.1136/thx.51.12.1178. Thorax. 1996. PMID: 8994512 Free PMC article. Clinical Trial.
RESULTS: There was no difference in baseline lung function, EAR, LAR, or in airway responsiveness to histamine before and after allergen between placebo and LY293111. By contrast, treatment with LY293111 significantly reduced the number of neutrophils in BAL fluid e …
RESULTS: There was no difference in baseline lung function, EAR, LAR, or in airway responsiveness to histamine before and after allergen bet …
Randomized, double-blind, phase II trial comparing gemcitabine-cisplatin plus the LTB4 antagonist LY293111 versus gemcitabine-cisplatin plus placebo in first-line non-small-cell lung cancer.
Jänne PA, Paz-Ares L, Oh Y, Eschbach C, Hirsh V, Enas N, Brail L, von Pawel J. Jänne PA, et al. J Thorac Oncol. 2014 Jan;9(1):126-31. doi: 10.1097/JTO.0000000000000037. J Thorac Oncol. 2014. PMID: 24346102 Free article. Clinical Trial.
INTRODUCTION: In this phase II study, patients with stage IIIB/IV non-small-cell lung cancer were randomly assigned (1:1:1) to receive LY293111 (200 mg twice daily [200 LY293111] or 600 mg twice daily [600 LY293111]) or placebo for 7 days, followed by concurr …
INTRODUCTION: In this phase II study, patients with stage IIIB/IV non-small-cell lung cancer were randomly assigned (1:1:1) to receive LY …
Gateways to clinical trials.
Bayes M, Rabasseda X, Prous JR. Bayes M, et al. Methods Find Exp Clin Pharmacol. 2006 Dec;28(10):719-40. Methods Find Exp Clin Pharmacol. 2006. PMID: 17235418
This issue focuses on the following selection of drugs: 5-Methyltetrahydrofolate, 9-aminocamptothecin; AdPEDF.11, AE-37, albumin interferon alfa, alicaforsen sodium, alvocidib hydrochloride, AMG-706, arginine butyrate, avanafil, axitinib, azimilide hydrochloride; BAY-579352, bela …
This issue focuses on the following selection of drugs: 5-Methyltetrahydrofolate, 9-aminocamptothecin; AdPEDF.11, AE-37, albumin interferon …
A phase I study of oral LY293111 given daily in combination with irinotecan in patients with solid tumours.
Baetz T, Eisenhauer E, Siu L, MacLean M, Doppler K, Walsh W, Fisher B, Khan AZ, de Alwis DP, Weitzman A, Brail LH, Moore M. Baetz T, et al. Invest New Drugs. 2007 Jun;25(3):217-25. doi: 10.1007/s10637-006-9021-8. Epub 2006 Dec 5. Invest New Drugs. 2007. PMID: 17146732 Clinical Trial.
In addition the anti-tumour activity of LY293111 in combination with irinotecan was documented. PATIENTS AND METHODS: Twenty-eight patients with advanced solid tumours were treated on seven dose levels with the combination of irinotecan and LY293111. ...Subsequently …
In addition the anti-tumour activity of LY293111 in combination with irinotecan was documented. PATIENTS AND METHODS: Twenty-eight pa …
Leukotriene B4 receptor antagonist LY293111 induces S-phase cell cycle arrest and apoptosis in human pancreatic cancer cells.
Tong WG, Ding XZ, Talamonti MS, Bell RH, Adrian TE. Tong WG, et al. Anticancer Drugs. 2007 Jun;18(5):535-41. doi: 10.1097/01.cad.0000231477.22901.8a. Anticancer Drugs. 2007. PMID: 17414622
The expression of cyclin-dependent kinase inhibitors, p21 and p27 was not affected by LY293111 treatment. In conclusion, LY293111 induces apoptosis in human pancreatic cancer cells through the mitochondria-mediated pathway. LY293111 also induces S-phase arres …
The expression of cyclin-dependent kinase inhibitors, p21 and p27 was not affected by LY293111 treatment. In conclusion, LY293111 …
Leukotriene B4-induced neutrophil extracellular traps impede the clearance of Pneumocystis.
Zhou Y, Deng S, Du C, Zhang L, Li L, Liu Y, Wang Y, Zhang Y, Zhu L. Zhou Y, et al. Eur J Immunol. 2024 Mar 5:e2350779. doi: 10.1002/eji.202350779. Online ahead of print. Eur J Immunol. 2024. PMID: 38440842
Mechanically, Pneumocystis triggered Leukotriene B4 (LTB4)-dependent neutrophil swarming, leading to agglutinative NET formation. Blocking Leukotriene B4 with its receptor antagonist Etalocib significantly reduced the accumulation and NET release of neutrophils in vitro an …
Mechanically, Pneumocystis triggered Leukotriene B4 (LTB4)-dependent neutrophil swarming, leading to agglutinative NET formation. Blocking L …
Preclinical characterization of 2-[3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic acid metabolism: in vitro species comparison and in vivo disposition in rats.
Perkins EJ, Cramer JW, Farid NA, Gadberry MG, Jackson DA, Mattiuz EL, O'Bannon DD, Weiss HJ, Wheeler WJ, Wood PG, Cassidy KC. Perkins EJ, et al. Drug Metab Dispos. 2003 Nov;31(11):1382-90. doi: 10.1124/dmd.31.11.1382. Drug Metab Dispos. 2003. PMID: 14570771
In vivo metabolites of LY293111 were examined in plasma, bile, urine, and feces of Fischer 344 (F344) rats after oral administration of [14C]LY293111. Metabolites were profiled by high-performance liquid chromatography-radiochromatography, and identified by liquid c …
In vivo metabolites of LY293111 were examined in plasma, bile, urine, and feces of Fischer 344 (F344) rats after oral administration …
Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells.
Tong WG, Ding XZ, Hennig R, Witt RC, Standop J, Pour PM, Adrian TE. Tong WG, et al. Clin Cancer Res. 2002 Oct;8(10):3232-42. Clin Cancer Res. 2002. PMID: 12374694
PURPOSE: The effects of leukotriene (LT) B4 and its receptor antagonist LY293111 on proliferation and apoptosis of human pancreatic cancer cells were investigated, both in vitro and in vivo. ...The growth-stimulatory effect and ERK1/2 phosphorylation induced by LTB4 were i …
PURPOSE: The effects of leukotriene (LT) B4 and its receptor antagonist LY293111 on proliferation and apoptosis of human pancreatic c …
46 results